| Project/Area Number |
15K20954
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Enomoto Yutaka 東京大学, 分子細胞生物学研究所, 助教 (20608210)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NK細胞 / IL-4 / IL-15 / マクロファージ |
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| Outline of Final Research Achievements |
The roles of NK cells in Th2-type responses have remained unclear. We examined the characteristics of NK cells in mice overexpressing IL-4. We found that IL-4 overexpression induces distinctive characteristics of NK cells, which are different from mature conventional NK (cNK) cells. IL-4 overexpression induces proliferation of tissue-resident macrophages, which contributes to NK cell proliferation via production of IL-15. These IL-4-induced NK cells (IL4-NK cells) produce higher levels of IFN-γ, IL-10, and GM-CSF, and exhibit high cytotoxicity compared with cNK cells. Finally, parasitic infection, which typically causes strong Th2-type responses, induces the development of NK cells with characteristics similar to IL4-NK cells. These results suggest a novel role of IL-4 in immune responses through the induction of the unique NK cells.
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