| Project/Area Number |
15K20963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAHIRA Shinya 東京大学, 大学院工学系研究科(工学部), 特別研究員 (70750652)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PEG脂質 / ケージド化合物 / 多種細胞パターニング / 血中循環がん細胞 / 光応答性化合物 / 界面科学 / 細胞センサ / 血中循環ガン細胞 / 細胞パターニング / 刺激応答性材料 / システムオンチップ / 一細胞解析 |
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| Outline of Final Research Achievements |
The technology of patterning of multi-types of cells has expected as a powerful tool in next-generation cell research. In this study, we developed a photo-activatable PEG-lipid which can immobilize cells by light irradiation, as a molecule that enables multi-patterning of cells. On the surface modified with this molecule, versatile and high-throughput patterning of multi-types of cells were performed by repeating a process of light irradiation, seeding of arbitrary types of cells and washing. Additionally, by light-trapping only the target cells on this surface, it was possible to capture and isolate important cells such as circulating cancer cells from peripheral blood.
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