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Pathological analysis of Apert syndrome mice model in submandibular gland

Research Project

Project/Area Number 15K20968
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Morphological basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Morita Jumpei  九州歯科大学, 歯学部, 助教 (50737046)

Research Collaborator YAMAJI Kojiro  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsApert症候群 / 唾液腺 / 先天性疾患 / 矯正歯科 / 線維芽細胞増殖因子受容体
Outline of Final Research Achievements

Apert syndrome is characterized by craniosynostosis and severe bony syndactyly of the hands and feet. The cause of Apert syndrome is a single nucleotide substitution mutation (S252W or P253R) in fibroblast growth factor receptor 2 (FGFR2). Clinical experience suggests increased production of saliva by Apert syndrome patients, but this has not been formally investigated. Using Apert syndrome mice model, we investigated the role of FGFR2 in SMGs and analyzed the SMG pathology of Apert syndrome.
In Ap mice, the number of lobules was small and the average area of lobules and the parenchyma occupancy rate were large compared with controls. Ap mice showed morphological changes in the SMGs, which are likely to be caused by gain-of-function of FGFR2, suggesting the possibility that epithelial cell proliferation is enhanced.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2015 Other

All Journal Article (1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] 本邦における外科的矯正治療症例の統計的検討2015

    • Author(s)
      川元龍夫、森田淳平、一田利道、福留由貴、池田恵理奈、瀧口玲子、郡司掛香織、黒石加代子
    • Journal Title

      九州歯科学会誌

      Volume: 69(4) Pages: 87-93

    • Related Report
      2015 Research-status Report
  • [Presentation] 顎下腺におけるApert症候群モデルマウスの病態解析2017

    • Author(s)
      山地晃二郎、森田順平、郡司掛香織、志賀百年、川元龍夫
    • Organizer
      第12回九州矯正歯科学会大会
    • Place of Presentation
      宮崎
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Characteristic Orofacial Phenotypes in a Patient Diagnosed with Orofaciodigital Syndrome1.2015

    • Author(s)
      Morita J., Tsuji M., Uezono M., Moriyama K.
    • Organizer
      The 8th International Orthodontic Congress
    • Place of Presentation
      London (England)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 公立大学法人 九州歯科大学

    • URL

      http://www.kyu-dent.ac.jp

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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