Elucidation of the role of oxygen-dependent dioxygenases on the development of tumor microenvironments
| Project/Area Number |
15K20970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tabu Kouichi 東京医科歯科大学, 難治疾患研究所, 助教 (10466469)
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| Research Collaborator |
TAGA Tetsuya 東京医科歯科大学, 難治疾患研究所, 教授 (40192629)
KIMURA Taichi 北海道大学, 医学研究科, 特任助教 (90435959)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / 微小環境 / マクロファージ / 鉄 / ストレス応答 |
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| Outline of Final Research Achievements |
This study has been carried out with the aim of elucidating the mechanisms how tumor microenvironments are developed during tumor progression. We have revealed that a subpopulation of glioma cells induces macrophages expressing iron-recycling genes under the iron-deficient stress, which suggests that stress response by tumor cells plays important roles in the development of tumor microenvironments. We also found that the induction of macrophages is potentially mediated by the epigenetic upregulation of CCL2 and GMCSF genes in tumor cells. Our findings could help establish new strategies for cancer therapy targeting microenvironments.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche.2016
Author(s)
Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, Taga T.
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Journal Title
Stem Cells
Volume: 34
Issue: 5
Pages: 1151-1162
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification and analysis of CXCR4-positive synovial sarcoma initiating cells.2016
Author(s)
Kimura T, Wang L, Tabu K, Tsuda M, Tanino M, Maekawa A, Nishihara H, Hiraga H, Taga T, Oda Y, Tanaka S.
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Journal Title
Oncogene
Volume: 未定
Issue: 30
Pages: 3932-3943
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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