• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the role of oxygen-dependent dioxygenases on the development of tumor microenvironments

Research Project

Project/Area Number 15K20970
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Pathological medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Tabu Kouichi  東京医科歯科大学, 難治疾患研究所, 助教 (10466469)

Research Collaborator TAGA Tetsuya  東京医科歯科大学, 難治疾患研究所, 教授 (40192629)
KIMURA Taichi  北海道大学, 医学研究科, 特任助教 (90435959)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords癌 / 微小環境 / マクロファージ / 鉄 / ストレス応答
Outline of Final Research Achievements

This study has been carried out with the aim of elucidating the mechanisms how tumor microenvironments are developed during tumor progression. We have revealed that a subpopulation of glioma cells induces macrophages expressing iron-recycling genes under the iron-deficient stress, which suggests that stress response by tumor cells plays important roles in the development of tumor microenvironments. We also found that the induction of macrophages is potentially mediated by the epigenetic upregulation of CCL2 and GMCSF genes in tumor cells. Our findings could help establish new strategies for cancer therapy targeting microenvironments.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] University of Edinburgh(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Edinburgh(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation2017

    • Author(s)
      Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI and Taga T
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42070-42070

    • DOI

      10.1038/srep42070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes2016

    • Author(s)
      Murota Y, Tabu K and Taga T
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 847-847

    • DOI

      10.1186/s12885-016-2895-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche.2016

    • Author(s)
      Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, Taga T.
    • Journal Title

      Stem Cells

      Volume: 34 Issue: 5 Pages: 1151-1162

    • DOI

      10.1002/stem.2299

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of protumoral CD11c[high] macrophages by glioma cancer stem cells thorough GM-CSF2016

    • Author(s)
      Kokubu et al
    • Journal Title

      Genes to Cells

      Volume: 21 Issue: 3 Pages: 241-251

    • DOI

      10.1111/gtc.12333

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification and analysis of CXCR4-positive synovial sarcoma initiating cells.2016

    • Author(s)
      Kimura T, Wang L, Tabu K, Tsuda M, Tanino M, Maekawa A, Nishihara H, Hiraga H, Taga T, Oda Y, Tanaka S.
    • Journal Title

      Oncogene

      Volume: 未定 Issue: 30 Pages: 3932-3943

    • DOI

      10.1038/onc.2015.461

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo.2015

    • Author(s)
      Inagaki T , Kusunoki S, Tabu K, Okabe H , Yamada I , Taga T , Matsuomoto A , Makino S , Takeda S , Kato K
    • Journal Title

      Human Cell

      Volume: 29 Issue: 1 Pages: 10-21

    • DOI

      10.1007/s13577-015-0121-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Self-maintenance strategies of glioma stem cells (GSCs) involving GSC-induced protumoral macrophages2017

    • Author(s)
      Tabu K and Taga T
    • Organizer
      第11回研究所ネットワーク国際シンポジウム
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Adaptive response of C6 glioma stem cells to iron deprivation through macrophage induction2016

    • Author(s)
      Tabu K, Wang W, Murota Y and Taga T
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Enhancement of 5-aminolevulinic acid-based fluorescence detection of glioma stem cells by chelating iron2016

    • Author(s)
      Wang W, Tabu K, Hagiya Y, Murota Y, Ogura SI and Taga T
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Adaptive response of rat C6 glioma stem cells to iron deprivation by which the development of tumor infiltrating macrophages is induced2016

    • Author(s)
      Tabu K, Kokubu Y, Muramatsu N, Nomoto S, Wang W and Taga T
    • Organizer
      第14回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Resistance of glioma stem cells to 5-aminolevulinic acid (ALA)-based detection due to enhanced metabolic conversion of protoporphyrin IX2016

    • Author(s)
      Wang W, Tabu K, Sugiyama Y, Hagiya Y, Ogura SI and Taga T
    • Organizer
      第14回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] C6 glioma stem cell-derived extracellular vesicles promote the development of macrophages2016

    • Author(s)
      Murota Y, Tabu K and Taga T
    • Organizer
      第14回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthetic polymer-based approach revealed an adaptive capacity of glioma stem cells by inducing tumor-infiltrating and iron-accumulating macrophages2015

    • Author(s)
      Kouichi Tabu, Nozomi Muramatsu, and Tetsuya Taga
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Splenic abnormal erythropoiesis in C6 glioma-bearing mice: an implication for their environment of cancer stem cells2015

    • Author(s)
      Wenqian Wang, Kouichi Tabu, Yasuhiro Kokubu, Yuichiro Hagiya, Shun-ichiro Ogura, and Tetsuya Taga
    • Organizer
      第74回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Characterization of C6 glioma cancer stem cells and their niche2015

    • Author(s)
      Taga T and Tabu K
    • Organizer
      Seoul National University, Cancer Research Institute (SNUCRI) Annual Symposium 2015 ‘Innovative Approaches to Explore Novel Druggable Targets’
    • Place of Presentation
      Hwasun Kumho Resort (Hwasun, Korea)
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
  • [Book] 合成ポリマーを用いた癌幹細胞ニッチの特性解明 (バイオマテリアル -生体材料-)2017

    • Author(s)
      椨康一、室田吉貴、田賀哲也
    • Total Pages
      82
    • Publisher
      日本バイオマテリアル学会
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京医科歯科大学プレスリリース

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20170207_1.pdf

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京医科歯科大学プレスリリース

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20160129.pdf

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi