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The development of new evaluation system for chronic pain with QST and CPM

Research Project

Project/Area Number 15K20975
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Anesthesiology
Research InstitutionMeikai University

Principal Investigator

Oono Yuka  明海大学, 歯学部, 准教授 (70451961)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
KeywordsQST / CPM / 冷温パルス刺激 / 逆説的温感覚(冷温錯感覚) / 慢性疼痛患者 / 病態評価法 / 定量的感覚試験(QST) / 条件刺激性疼痛調節(CPM)
Outline of Final Research Achievements

The simultaneous cold-heat pulse stimulation (combination of cold stimulus and heat stimulus; modified from quantitative sensory testing; QST) evoked the paradoxical thermal sensations and provoked CPM in healthy volunteers. There was a relationship between CPM effect and the paradoxical thermal sensations to cold-heat pulse stimulation. In addition, in patients scheduled for dental surgery, there was a relationship between postoperative pain, CPM and the paradoxical thermal sensations to cold-heat pulse stimulation. The differences in sensations triggered by cold-heat pulse stimulation and CPM could be used for the discrimination of the pain pattern, and it leads to the development of new evaluation system for chronic pain with QST and CPM.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] メトクロプラミド投与後に痙攣発作を生じたSturge-Weber症候群の1例2017

    • Author(s)
      松村 真由美, 高島 恵子, 田島 徹, 内田 茂則, 小林 克江, 高木 沙央理, 大野 由夏, 牧野 兼三, 小長谷 光
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 46 Pages: 40-42

    • NAID

      130006313414

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 新たに開発した定量的熱刺激装置2016

    • Author(s)
      今村敏克、久保英範、松本勝洋、髙島恵子、内田茂則、髙木沙央理、大野由夏、小長谷光
    • Journal Title

      明海歯科医学

      Volume: 46 Pages: 40-46

    • NAID

      40021106370

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 非侵害性温度条件刺激によるconditioned pain modulation効果2016

    • Author(s)
      大野由夏、久保英範、松本勝洋、髙島恵子、今村敏克、内田茂則、髙木沙央理、小長谷光
    • Journal Title

      明海歯科医学

      Volume: 46 Pages: 34-39

    • NAID

      40021106344

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] The subjective sensation induced by various thermal pulse stimulation in healthy volunteers2017

    • Author(s)
      Oono Y, Kubo H, Imamura T, , Matsumoto K, Uchida S, Takagi S, Gazerani P, Wang K, Arendt-Nielsen L, Kohase H.
    • Organizer
      The Scandinavian Association for the Study of Pain (SASP) Annual Meeting
    • Place of Presentation
      Aalborg, Denmark
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] THE RELATIONSHIP BETWEEN PARADOXICAL THERMAL SENSATIONS AND CONDITIONED PAIN MODULATION BY COLD-HEAT PULSE CONDITIONING STIMULATION IN HEALTHY VOLUNTEERS2017

    • Author(s)
      Oono Y, Kubo H, Imamura T, Matsumoto K, Takashima K, Uchida S, Takagi S, Kobayashi K, Makino K, Nagasaka H, Gazerani P, Wang K, Arendt-Nielsen L, Kohase H
    • Organizer
      The 10th Congress of the European Pain Federation, EFIC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NOCIFENSIVE RESPONSES IN OVARIECTOMIZED RATS FOLLOWING INJECTION OF NERVE GROWTH FACTOR INTO TONGUE TISSUE: A NEW MODEL TOWARDS UNDERSTANDING POTENTIAL MECHANISMS OF BURNING MOUTH SYNDROME2017

    • Author(s)
      Matsumoto K, Oyake H, Poulsen J, Oono Y, Amano O, Gazerani P, Arendt-Nielsen L, Kohase H
    • Organizer
      The 10th Congress of the European Pain Federation, EFIC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of the remifentanil on bispectral index values and 95% sepectral edge frequency under nitrous oxide- sevoflurane anesthesia2017

    • Author(s)
      Mieda T, Nagasaka H, Nakamura T, Yuta Horikoshi Y, Nogi T, Hoshijima H, Nishizawa S, Ide Y, Oono Y, Kohase H
    • Organizer
      The 10th Congress of the European Pain Federation, EFIC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The subjective sensation induced by various thermal pulse stimulation in healthy volunteers2017

    • Author(s)
      Oono Y, Kubo H, Imamura T, Matsumoto K, Uchida S, Takagi S, Gazerani P, Wang K, Arendt-Nielsen L, Kohase H
    • Organizer
      SASP ANNUAL MEETING
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 遷延性術後痛 Conditioned pain modulationを応用した痛みの識別と痛みのリスクファクター2017

    • Author(s)
      大野 由夏, 小長谷 光
    • Organizer
      日本ペインクリニック学会 第51回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 健康成人における様々な温度パルス刺激による主観的感覚評価2017

    • Author(s)
      大野 由夏, 久保 英範, 松本 勝洋, 高島 恵子, 早川 華穂, 内田 茂則, 高木 沙央理, 長坂 浩, 小長谷 光
    • Organizer
      日本ペインクリニック学会 第51回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Conditioned pain modulationとthermal pain illusionは術後痛発症予測のバイオマーカーとなるか2017

    • Author(s)
      高島 恵子, 大野 由夏, 今村 敏克, 久保 英範, 松本 勝洋, 松村 真由美, 小宅 宏史, 内田 茂則, 高木 沙央理, 小林 克江, 牧野 兼三, 西澤 秀哉, 星島 宏, 長坂 浩, 小長谷 光
    • Organizer
      第45回日本歯科麻酔学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 健康成人におけるThermal Pain Illusionとその発生メカニズム2017

    • Author(s)
      大野 由夏、今村 敏克、内田 茂則、髙木 沙央理、長坂 浩、小長谷 光
    • Organizer
      日本麻酔科学会第64回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 冷温交互刺激で生じる錯感覚と条件刺激性疼痛調節との関連2016

    • Author(s)
      久保英範 今村敏克, 松本勝洋, 高島恵子, 小宅宏史, 牧野兼三, 小林克江, 西澤秀哉, 星島宏, 内田茂則, 高木沙央理, 大野由夏, 長坂浩, 長谷川彰彦, 小長谷光
    • Organizer
      第44回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      札幌、北海道
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] The relationship between paradoxical sensation and conditioned pain modulation by cold-warm pulse conditioning stimulation in healthy volunteers2016

    • Author(s)
      Oono Y, Imamura T, Kubo H, Matsumoto K, Uchida S, Takagi S, Makino K, Nagasaka H, Gazerani P, Wang K, Arendt-Nielsen L, Kohase H.
    • Organizer
      The 16th World Congress on Pain
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] P2X3 Positive Nerve Fibers outside the Gustatory Papillae in Rat2016

    • Author(s)
      Matsumoto K, Poulsen J, Oono Y, Kohase H, Gazerani P, Arendt-Nielsen L
    • Organizer
      The 16th World Congress on Pain
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 冷温交互刺激で生じる錯感覚とConditioned Pain Modulation(CPM)の関連2016

    • Author(s)
      久保英範、松本勝洋、大野由夏、小長谷光
    • Organizer
      第21回日本口腔顔面痛学会学術大会
    • Place of Presentation
      横浜市、神奈川県
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 非侵害温刺激と非侵害冷温同時刺激はconditioned pain modulationを誘発した2016

    • Author(s)
      大野由夏, 久保英範, 松本勝洋, 黒田翔太, 早川華穂, 内田茂則, 高木 沙央理, 牧野 兼三, 長坂 浩, 小長谷 光
    • Organizer
      日本ペインクリニック学会第50回大会
    • Place of Presentation
      横浜市、神奈川県
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 健康成人における冷温パルス刺激可能な定量的熱刺激装置を用いたConditioned Pain Modulation評価2016

    • Author(s)
      大野由夏、今村敏克、内田茂則、髙木沙央理、長坂浩、小長谷光
    • Organizer
      日本麻酔科学会 第63回学術集会
    • Place of Presentation
      福岡県、博多市
    • Year and Date
      2016-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Conditioned pain modulation in healthy volunteers evaluated with a new custom-made quantitative cold pain stimulator.2015

    • Author(s)
      Oono Y, Imamura T, Ogami S, Hasegawa A, Nagasaka H, Wang K, Arendt-Nielsen L, Kohase H.
    • Organizer
      9th Congress of the European Federation of IASP Chapters (EFIC)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Endogenous Pain Modulation: Test methodology2015

    • Author(s)
      Lars Arendt-Nielsen, Yuka Oono
    • Organizer
      9th Congree of the EFIC REFRESHER course
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 9th Congree of the EFIC REFRESHER course book2015

    • Author(s)
      Lars Arendt-Nielsen, Yuka Oono
    • Total Pages
      139
    • Publisher
      IASP press
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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