Identification of miRNAs inducing synthetic lethality in ATL cells
| Project/Area Number |
15K21003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
Tumor therapeutics
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| Research Institution | Aichi Gakuin University (2016)
Niigata University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ATL / miRNA / HTLV-1 / microRNA / 合成致死 |
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| Outline of Final Research Achievements |
Adult T-cell leukemia (ATL) is caused by the infection with Human T-cell leukemia virus type I (HTLV-1). The patients with ATL show a poor prognosis. Effective treatment of ATL has not been established yet. In this project, we attempted to identify the miRNAs selectively affecting the viability of ATL cells. First, we employed a bioinformatics analysis to predict the miRNA which dominantly target the genes required for the survival of HTLV-I-transformed cells. The results of the computational prediction were verified in HTLV-1-transformed cells and HTLV-1-negative human T cell lines. Overexpression of miRNAs reduces the viability of HTLV-1-transformed cells but not HTLV-1-negative cells. These results suggest that certain miRNAs might be a novel therapeutic agent against ATL.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016
Author(s)
Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
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Journal Title
Stem Cell Reports
Volume: ７
Issue: 6
Pages: 1116-1129
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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