| Project/Area Number |
15K21003
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
Tumor therapeutics
|
|---|
| Research Institution | Aichi Gakuin University (2016)
Niigata University (2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ATL / miRNA / HTLV-1 / microRNA / 合成致死 |
|---|
| Outline of Final Research Achievements |
Adult T-cell leukemia (ATL) is caused by the infection with Human T-cell leukemia virus type I (HTLV-1). The patients with ATL show a poor prognosis. Effective treatment of ATL has not been established yet. In this project, we attempted to identify the miRNAs selectively affecting the viability of ATL cells. First, we employed a bioinformatics analysis to predict the miRNA which dominantly target the genes required for the survival of HTLV-I-transformed cells. The results of the computational prediction were verified in HTLV-1-transformed cells and HTLV-1-negative human T cell lines. Overexpression of miRNAs reduces the viability of HTLV-1-transformed cells but not HTLV-1-negative cells. These results suggest that certain miRNAs might be a novel therapeutic agent against ATL.
|
