| Project/Area Number |
15K21004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
Eating habits
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 米胚乳タンパク質 / 米糠タンパク質 / CKD-MBD / ZDFラット / ＺＤＦラット / 慢性腎臓病 / 骨・ミネラル代謝異常 / 糖尿病性腎症 |
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| Outline of Final Research Achievements |
In this study, we attempted to clarify effects of rice endosperm protein (RBP) and rice bran protein (RBP) on chronic kidney disease-mineral and bone disorder (CKD-MBD) in type 2 diabetic model rats. Male ZDF rats rats were employed and fed a REP and RBP diet for 10 weeks. Hemoglobin A1c, a marker for diabetes, and urinary albumin excretion, a diagnostic criterion of diabetic nephropathy, were significantly suppressed by consuming REP and RBP compared with casein (C). These results strongly suggest that REP and RBP ameliorated diabetes and diabetic nephropathy. Fibroblast growth factor 23, one of the regulating factors for phosphate in blood, in the REP and RBP groups significantly suppressed compared with the C group. In addition, femoral microstructures and bone strength deteriorated in ZDF rats compared with non-diabetic rats but the deterioration was suppressed by REP and RBP consumptions. Therefore, it is indicated that REP and RBP had suppressive effects on CKD-MBD in ZDF rats.
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