The role of cortico-hippocampal interaction for systems consolidation

• Project/Area Number: 15K21013
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience; Basic / Social brain science
• Research Institution: Tokyo University of Science (2016); University of Toyama (2015)
• Principal Investigator: Sano Yoshitake 東京理科大学, 理工学部応用生物科学科, 助教 (90415175)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 記憶 / 大脳皮質 / 海馬 / Systems consolidation / エングラム / 永続的記憶 / 海馬-大脳皮質

Outline of Final Research Achievements

We addressed the mechanism for systems consolidation and especially tested the hypothesis that “cortico-hippocampal co-activation following learning has an impact on systems consolidation”. To address this hypothesis, we developed the systems labeling and manipulating cell assembly activated during learning. Then, cortico-hippocampal neurons activated during learning were co-stimulated during sleep after learning. We observed mice tended to show that memory generalization was enhanced and hippocampal-dependency for memory retrieval was decreased. But to confirm these results, we have to improve methods for activating cell assembly.

Research Products

• [Journal Article] The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination (2017)
  • Author(s): Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, and Furuichi T.
  • Journal Title: PLoS ONE Volume: 12 Issue: 3 Pages: e0173175-e0173175
  • DOI: 10.1371/journal.pone.0173175
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory (2016)
  • Author(s): Miou Zhou, Stuart Greenhill, Shan Huang, Tawnie K Silva, Yoshitake Sano, Shumin Wu, Ying Cai, Yoshiko Nagaoka, Megha Sehgal, Denise J Cai, Yong-Seok Lee, Kevin Fox and Alcino J Silva.
  • Journal Title: eLIFE Volume: 5
  • DOI: 10.7554/elife.20985
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mammalian-specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments (2016)
  • Author(s): Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Furuse, T., Sadakata, T., Tanaka, M., Shinoda, Y., Hashikawa, T., Itohara, S., Sano, Y., Ghandour, SM., Wakana, S., and Furuichi, T.
  • Journal Title: PLoS ONE Volume: 11 Issue: 11 Pages: e0166732-e0166732
  • DOI: 10.1371/journal.pone.0166732
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories (2016)
  • Author(s): Thomas Rogerson, Balaji Jayaprakash, Denise J Cai, Yoshitake Sano, Yong-Seok Lee, Yu Zhou, Pallavi Bekal, Karl Deisseroth and Alcino J Silva.
  • Journal Title: PLoS ONE Volume: 11 Issue: 8 Pages: e0161655-e0161655
  • DOI: 10.1371/journal.pone.0161655
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus (2016)
  • Author(s): 6.Shinoda Y, Ishii C, Fukazawa Y, Sadakata T, Ishii Y, Sano Y, Iwasato T, Itohara S, Furuichi T
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 31540-31540
  • DOI: 10.1038/srep31540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A shared neural ensemble links distinct contextual memories encoded close in time (2016)
  • Author(s): Denise J. Cai, Daniel Aharoni, Tristan Shuman, Justin Shobe, Jeremy Biane, Weilin Song, Brandon Wei, Michael Veshkini, Mimi La-Vu, Jerry Lou, Sergio Flores, Isaac Kim, Yoshitake Sano, Miou Zhou, Karsten Baumgaerte, Ayal Lavi, Masakazu Kamata, Mark Tuszynski, Mark Mayford, Peyman Golshani and Alcino J. Silva
  • Journal Title: Nature Volume: 534 Issue: 7605 Pages: 115-115
  • DOI: 10.1038/nature17955
  • Peer Reviewed / Int'l Joint Research
• [Presentation] A deficiency of Ca2+ -dependent activator protein for secretion 1 affects hippocampal long-term potentiation (2016)
  • Author(s): Y.ISHII, C.ISHII, Y.SHINODA, Y.SANO and T.FRUICHI
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Adaptor protein, X11 and X11L have distinct roles in exploratory activity. (2016)
  • Author(s): T. SATO, R. MOTODATE, Y. SANO, S. KAMADA, S. UCHIDA, T. SUZUKI
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Linking memories across time (2016)
  • Author(s): D. J. CAI, D. AHARONI, T. SHUMAN, J. SHOBE, J. BIANE6, W. SONG, B. WEI, M. VESHKINI, M. LA-VU, J. LOU, S. FLORES, I. KIM, Y. SANO, M. ZHOU, K. BAUMGAERTEL, A. LAVI, M. KAMATA, M. TUSZYNSKI, M. MAYFORD, P. GOLSHANI and A. J. SILVA
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Role of CCR5 in learning and memory and in HIV V3 peptide induced cognitive deficits (2016)
  • Author(s): M. ZHOU, S. GREENHILL, S. HUANG, T. SILVA, Y. SANO, S. WU, Y. CAI, Y. NAGAOKA, M. SEHGAL, D. CAI, Y.-S. LEE, K. FOX and A. J. SILVA
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] メモリーアロケーションの神経基盤 ～これから起きる出来事はどの神経細胞に保存されるのか？～ (2016)
  • Author(s): 佐野 良威
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学 (神奈川県 藤沢市)
  • Year and Date: 2016-09-06
  • Invited
• [Book] 生体の科学 67(1)「記憶痕跡とメモリーアロケーション」 (2016)
  • Author(s): 佐野 良威、大川 宜昭、鈴木 章円、井ノ口 馨
  • Total Pages: 92
  • Publisher: 金原一郎記念医学医療振興財団
• [Book] 生体の科学 67 「記憶痕跡とメモリーアロケーション」 (2016)
  • Author(s): 佐野 良威、大川 宜昭、鈴木 章円、井ノ口 馨
  • Total Pages: 5
  • Publisher: 医学書院