Elucidation of immune condition in diabetic patients induced carcinogenic susceptibility

• Project/Area Number: 15K21022
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: Takuya Komura 金沢大学, 医学系, 協力研究員 (90623322)
• Research Collaborator: Sakai Yoshio 金沢大学, 医学系, 准教授 (80401925)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 糖尿病 / 易発がん / 免疫状態 / 担癌状態 / 耐糖能異常 / マクロファージ / NASHマウスモデル

Outline of Final Research Achievements

We could establish a murine model of impaired glucose tolerance.
Next, We also could establish a murine model of pancreatic ductal adenocarcinoma model. We disclosed that frequency of myeloid derived suppressor cells was increased along increment of tumor size in this tumor bearing mice.

Research Products

• [Journal Article] Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact. (2015)
  • Author(s): Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Honda M, Ohta T, Nakanuma Y, Kaneko S.
  • Journal Title: Cancer Sci. Volume: 106(6) Issue: 6 Pages: 672-86
  • DOI: 10.1111/cas.12663
  • Peer Reviewed / Open Access
• [Presentation] 膵臓癌マウスモデルにおける宿主免疫応答状態の解明 (2017)
  • Author(s): 小村卓也、酒井佳夫、高畠央、金子周一
  • Organizer: 日本膵臓学会
• [Presentation] 膵臓癌における宿主免疫応答状態の解明 (2016)
  • Author(s): 小村卓也
  • Organizer: JDDW
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2016-11-03
• [Presentation] The features of host immune response in patients with pancreatic ductal adenocarcinoma (2016)
  • Author(s): Takuya Komura
  • Organizer: UEGW
  • Place of Presentation: Austria (Wienna)
  • Year and Date: 2016-10-19
  • Int'l Joint Research
• [Presentation] The immune features in blood of patients with pancreatic ductal adenocarcinoma (2016)
  • Author(s): Takuya Komura
  • Organizer: 国際膵臓学会/日本膵臓学会 共催
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-08-04
  • Int'l Joint Research
• [Presentation] Inflammatory conditions of colorectal cancer inflammation are featured by monocytes/macrophages lineage and CD4+ T cells associated with their humoral mediators in blood. (2016)
  • Author(s): Takuya Komura, Yoshio Sakai, Hisashi Takabatake, Masaki Miyazawa1, Akihiro Seki, Hatsune Mochida, Masao Honda, Takashi Wada, Shuichi Kaneko
  • Organizer: 第10回 日米癌合同会議
  • Place of Presentation: マウイ島（アメリカ）
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Inflammatory Features of Pancreatic Cancer Highlighted by Monocytes/Macrophages and CD4+ T cells with Clinical Impact (2015)
  • Author(s): Takuya Komura, Yoshio Sakai, Takashi Wada, Shuichi Kaneko
  • Organizer: 日本免疫学会
  • Place of Presentation: 北海道（札幌）
  • Year and Date: 2015-11-18
• [Presentation] The high frequency of PD-1 in peripheral CD4+ T cells of Pancreatic Ductal Adenocarcinoma is potentially useful for development of the novel diagnostic methods and prediction of chemotherapy responsiveness. (2015)
  • Author(s): Takuya Komura, Yoshio Sakai, Takashi Wada, Shuichi Kaneko
  • Organizer: 2015 UEGW
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2015-10-24
  • Int'l Joint Research