Research on the neural basis and neurophysiological marker of reactive attachment disorder caused by childhood maltreatment using functional brain imaging

• Project/Area Number: 15K21026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics; Basic / Social brain science
• Research Institution: University of Fukui
• Principal Investigator: TAKIGUCHI Shinichiro 福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (70382926)
• Research Collaborator: TOMODA Akemi 福井大学, 子どものこころの発達研究センター, 教授 (80244135) ; FUJISAWA Takashi 福井大学, 子どものこころの発達研究センター, 特命講師 (90434894) ; SHIMADA Koji 福井大学, 子どものこころの発達研究センター, 特命助教 (00711128) ; KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 教授 (70401966) ; SAITO Daisuke 金沢大学, 子どものこころの発達研究センター, 准教授 (30390701)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 反応性愛着障害 / 児童虐待 / 脳画像解析 / fMRI / 報酬系 / VBM / 認知課題

Outline of Final Research Achievements

Childhood maltreatment is a major risk factor for reactive attachment disorder (RAD). We examined whether neural activity during reward processing was altered in children and adolescents with RAD using functional MRI. Significantly reduced activity in the striatum was observed in the RAD group compared with the TD group. And significant negative correlations between striatal activity and avoidant attachment were observed. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD. Another study examined the neural effects of intranasal oxytocin on reward processing in children with RAD. Male children with RAD and TD individuals performed monetary reward task during functional MRI. Oxytocin enhanced striatal activation in the RAD group by the analysis of reward sensitivity using task contrast, but not in the TD group. These findings indicate that oxytocin may promote reward processing in RAD.

Research Products

• [Journal Article] Subclinical maternal depressive symptoms modulate right inferior frontal response to inferring affective mental states of adults but not of infants (2018)
  • Author(s): Shimada K, Kasaba R, Fujisawa TX, Sakakibara N, Takiguchi S, Tomoda A
  • Journal Title: Journal of Affective Disorders Volume: 229 Pages: 32-40
  • DOI: 10.1016/j.jad.2017.12.031
  • Peer Reviewed / Open Access
• [Journal Article] Catechol-O-methyltransferase polymorphism is associated with the cortico-cerebellar functional connectivity of executive function in children with attention-deficit/hyperactivity disorder (2017)
  • Author(s): Mizuno Yoshifumi、Jung Minyoung、Fujisawa Takashi X.、Takiguchi Shinichiro、Shimada Koji、Saito Daisuke N.、Kosaka Hirotaka、Tomoda Akemi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 4850-4850
  • DOI: 10.1038/s41598-017-04579-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 養育者支援に関する脳科学的エビデンス (2017)
  • Author(s): 高田紗英子，榊原信子，島田浩二，藤澤隆史，西川里織，滝口慎一郎 ， 友田明美
  • Journal Title: 子どものこころと脳の発達 Volume: 8 Pages: 70-78
  • NAID: 40021386618
  • Peer Reviewed
• [Journal Article] Increased anterior pelvic angle characterizes the gait of children with attention deficit/hyperactivity disorder (ADHD). (2017)
  • Author(s): Naruse H, Fujisawa TX, Yatsuga C, Kubota M, Matsuo H, Takiguchi S, Shimada S, Imai Y, Hiratani M, Kosaka H, Tomoda A*.
  • Journal Title: PLoS One Volume: 12(1) Issue: 1 Pages: e0170096-e0170096
  • DOI: 10.1371/journal.pone.0170096
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders. (2016)
  • Author(s): Komeda, H., Osanai, H., Yanaoka, K., Okamoto, Y., Fujioka, T., Arai, S., Inohara, K., Koyasu, M., Kusumi, T., Takiguchi, S., Kawatani, M., Kumazaki, H., Hiratani, M., Tomoda, A., & Kosaka, H.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 37875-37875
  • DOI: 10.1038/srep37875
  • NAID: 120005890337
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Advanced test of attention in children with Attention-Deficit/Hyperactivity Disorder in Japan for evaluation of methylphenidate and atomoxetine effects. (2016)
  • Author(s): Fujioka T, Takiguchi S, Yatsuga C, Hiratani M, Hon K, Min-Sup S, Cho S, Kosaka H, Tomoda A.
  • Journal Title: Clin Psychopharmacology Neurosci, Volume: 14 Issue: 1 Pages: 79-87
  • DOI: 10.9758/cpn.2016.14.1.79
  • Peer Reviewed / Open Access
• [Journal Article] Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: A functional MRI Study. (2015)
  • Author(s): Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Koizumi M, Kumazaki H, Jung M, Kosaka H, Hiratani M, Ohshima Y, Teicher, MH, Tomoda A.
  • Journal Title: British Journal of Psychiatry Open Volume: 1 Issue: 2 Pages: 121-128
  • DOI: 10.1192/bjpo.bp.115.001586
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired neural reward processing in children and adolescents with reactive attachment disorder: A pilot study (2015)
  • Author(s): Mizuno K, Takiguchi S, Yamazaki M, Asano M, Kato S, Kuriyama K, Watanabe Y, Sadato N, Tomoda A.
  • Journal Title: Asian Journal of Psychiatry Volume: 17 Pages: 89-93
  • DOI: 10.1016/j.ajp.2015.08.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced visual cortex gray matter volume in children and adolescents with reactive attachment disorder. (2015)
  • Author(s): Shimada K, Takiguchi S, Mizushima S, Fujisawa TX, Saito DN, Kosaka H, Okazawa H, Tomoda A.
  • Journal Title: Neuroimage-Clinical Volume: 9 Pages: 13-19
  • DOI: 10.1016/j.nicl.2015.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the nature of subsequent environment on oxytocin and cortisol secretion in maltreated children. (2015)
  • Author(s): Mizushima SG, Fujisawa TX, Takiguchi S, Kumazaki H, Tanaka S, Tomoda A.
  • Journal Title: Frontiers in Psychiatry Volume: 6 Pages: 173-173
  • DOI: 10.3389/fpsyt.2015.00173
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ethnic differences in COMT genetic effects on striatal grey matter alterations associated with childhood ADHD: A voxel-based morphometry study in a Japanese sample. (2015)
  • Author(s): Shimada K, Fujisawa TX, Takiguchi S, Naruse H, Kosaka H, Okazawa H, Tomoda A.
  • Journal Title: World Journal of Biological Psychiatry Volume: 18 Issue: 4 Pages: 1-7
  • DOI: 10.3109/15622975.2015.1102325
  • Peer Reviewed / Open Access
• [Journal Article] Altered frontal pole development affects self-generated spatial working memory in ADHD. (2015)
  • Author(s): Arai S, Okamoto Y, Fujioka T, Inohara K, Ishitobi M, Matsumura Y, Jung M, Kawamura K, Takiguchi S, Tomoda A, Wada Y, Hiratani M, Matsuura N, Kosaka H.
  • Journal Title: Brain Dev Volume: S0387-7606 Issue: 5 Pages: 00235-1
  • DOI: 10.1016/j.braindev.2015.11.005
  • Peer Reviewed / Open Access
• [Presentation] 平谷美智夫、滝口慎一郎、川谷正男、巨田元礼 (2017)
  • Author(s): 発達性ディスレクシアと診断された224例の背景要因の検討
  • Organizer: 第71回日本小児神経学会北陸地方会
  • Place of Presentation: 金沢大学附属病院CPDセンター（石川県金沢市）
  • Year and Date: 2017-02-05
• [Presentation] 臨床と研究の融合―脳科学的視点から子どもの発達を考える (2017)
  • Author(s): 滝口慎一郎，水島栄，齋藤大輔
  • Organizer: 第23回日本子ども虐待防止学会 学術集会
• [Presentation] 乳幼児期のマルトリートメント、とくに低栄養経験が子どもの脳発達に及ぼす影響に関する研究 (2017)
  • Author(s): 滝口慎一郎，友田明美
  • Organizer: 第17回DIJFカンファランス
• [Presentation] White matter tract abnormalities in children with reactive attachment disorder: A diffusion tensor imaging study (2017)
  • Author(s): Takiguchi S, Naruse H, Shimada K, Fujisawa TX, Takada S, Morioka S, Shimoji K, Tomoda A
  • Organizer: The 12th International ISBS Regional Neuroscience and Biological Psychiatry (Asia) "Stress and Behavior" Conference
  • Int'l Joint Research
• [Presentation] 養育者の抑うつ気分が社会的認知とその脳機能に及ぼす影響に関する実験的研究 (2017)
  • Author(s): 島田浩二，笠羽涼子，藤澤隆史，榊原信子，滝口慎一郎，友田明美
  • Organizer: 第118回日本小児精神神経学会
• [Presentation] Attention to eye in still face strongly related to sociality compared to other social information in children with Autism Spectrum Disorder (2017)
  • Author(s): Fujioka T, Mizuno Y, Takiguchi S, Fujisawa TX,Tsuchiya KJ,Katayama T, Tomoda A, Hiratani M, Kosaka H
  • Organizer: AACAP's 64th Annual Meeting
  • Int'l Joint Research
• [Presentation] ADHD児におけるCOMT遺伝子多型と大脳皮質－小脳の実行機能ネットワークの関連 (2017)
  • Author(s): 水野賀史，丁ミンヨン，藤澤隆史，滝口慎一郎，島田浩二，齋藤大輔，小坂浩隆，友田明美
  • Organizer: 第44回日本脳科学会
• [Presentation] 反応性愛着障害児における小児期逆境経験のタイプとタイミングが脳灰白質減少に及ぼす影響 (2017)
  • Author(s): 藤澤隆史，島田浩二，滝口慎一郎，小坂浩隆，友田明美
  • Organizer: 第58回日本児童青年精神医学会総会
• [Presentation] 被虐待児の社会的認知に対するオキシトシン投与の有効性の検討 (2017)
  • Author(s): 小泉径子、藤岡徹、滝口慎一郎、水野賀史、石川俊介、升谷泰裕、松村由紀子、岡崎玲子、野路恵理佳、友田明美、小坂浩隆
  • Organizer: 第58回日本児童青年精神医学会総会
• [Presentation] 母親の感覚感受性のタイプが育児不安/養育ストレスに及ぼす影響 (2017)
  • Author(s): 榊原信子、滝口慎一郎、藤澤隆史、友田明美
  • Organizer: 第58回日本児童青年精神医学会総会
• [Presentation] 子どもに対する潜在的態度と養育ストレスの神経基盤 (2017)
  • Author(s): 藤澤隆史，西川里織，水野賀史，滝口慎一郎，島田浩二，友田明美
  • Organizer: 日本心理学会第81回大会
• [Presentation] 介入時の方法および道具を工夫したことにより，書字における読みやすさが向上した事例 (2017)
  • Author(s): 今井悠人，成瀬廣亮，滝口慎一郎，河野俊寛，平谷美智夫
  • Organizer: 第51回日本作業療法学会
• [Presentation] The altered cortico‐cerebellar network involved with COMT polymorphism in children with attention-deficit/hyperactivity disorder. (2017)
  • Author(s): 水野賀史，丁ミンヨン，藤澤隆史，滝口慎一郎，島田浩二，齋藤大輔，小坂浩隆，友田明美
  • Organizer: 第59回日本小児神経学会総会 English Session
• [Presentation] オキシトシン単回投与が非協力者の魅力度評価に与える影響 (2016)
  • Author(s): 小泉 径子、松村 由紀子、石川 俊介、升谷 泰裕、岡崎 玲子、岡本悠子、藤岡 徹、滝口 慎一郎、友田 明美、小坂 浩隆
  • Organizer: 第57 回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2016-10-27
• [Presentation] The abnormal regional neural function and functional integration of the cerebellum in children and adolescents with attentiondeficit/ hyperactivity disorder. (2016)
  • Author(s): Mizuno Y, Jung M, Fujisawa TX, Takiguchi S, Shimada K, Saito D, Kosaka H, Tomoda A.
  • Organizer: AACAP's 63rd Annual Meeting
  • Place of Presentation: New York, USA
  • Year and Date: 2016-10-24
  • Int'l Joint Research
• [Presentation] The effect of oxytocin on detection of altruistic person for children. (2016)
  • Author(s): Koizumi M, Matsumura Y, Ishikawa S, Matsumoto H, Masuya Y, Okazaki R, Okamoto Y, Fujioka T, Takiguchi S, Tomoda A, Kosaka H.
  • Organizer: The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) World Congress and the 36th CACAP Conference
  • Place of Presentation: Calgary, Canada
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] 反応性愛着障害における報酬機能不全 (2016)
  • Author(s): 滝口慎一郎、藤澤隆史、島田浩二、水島栄、齋藤大輔、岡本悠子、小坂浩隆、友田明美
  • Organizer: 第8回日本子ども虐待医学会学術集会
  • Place of Presentation: 福岡大学病院 福大メディカルホール（福岡県福岡市）
  • Year and Date: 2016-07-23
• [Presentation] The regional neural function and functional integration of the cerebellum in children with ADHD: A resting-state fMRI study. (2016)
  • Author(s): Mizuno Y, Jung M, Fujisawa TX, Shimada K, Takiguchi S, Saito D, Kosaka H, Tomoda A.
  • Organizer: The 8th International Neuroscience and Biological Psychiatry Regional “Stress and Behavior” Conference
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] The neural effects of intranasal oxytocin administration in reactive attachment disorder. (2016)
  • Author(s): Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Shimada K, Okamoto Y, Nishikawa S, Takada S, Mizuno Y, Kosaka H, Tomoda A.
  • Organizer: 第58回日本小児神経学会総会
  • Place of Presentation: 京王プラザホテル新宿（東京都新宿区）
  • Year and Date: 2016-06-03
• [Presentation] ADHD児における安静時の小脳の脳活動 (2016)
  • Author(s): 水野賀史、丁ミンヨン、藤澤隆史、滝口慎一郎、齋藤大輔、小坂浩隆、友田明美
  • Organizer: 第58回日本小児神経学会総会
  • Place of Presentation: 京王プラザホテル新宿（東京都新宿区）
  • Year and Date: 2016-06-03
• [Presentation] Altered brain response to reward in maltreated children and adolescents (2015)
  • Author(s): Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Shimada K, Kosaka H, Tomoda A
  • Organizer: The 13th Asian Congress of Health Promotion
  • Place of Presentation: Harbin, Harbin Medical University, China
  • Year and Date: 2015-12-13
  • Int'l Joint Research
• [Presentation] COMT 遺伝子多型が小児期 ADHD の線条体の灰白質異常に及ぼす影響 (2015)
  • Author(s): 島田浩二、藤澤隆史、滝口慎一郎、 成瀬廣亮、小坂浩隆、岡沢秀彦、 友田明美
  • Organizer: 第42 回日本脳科学会
  • Place of Presentation: 宮崎市, ANAホリデイ・イン リゾート宮崎
  • Year and Date: 2015-11-12
• [Presentation] Altered frontal pole development affecting self-generated working memory in children with ADHD (2015)
  • Author(s): 新井清義、岡本悠子、藤岡徹、猪 原敬介、石飛信、松村由紀子、丁 ミンヨン、河村佳保里、滝口慎一 郎、友田明美、和田有司、平谷美 智夫、松浦直己、小坂浩隆
  • Organizer: 第42 回日本脳科学会
  • Place of Presentation: 宮崎市, ANAホリデイ・イン リゾート宮崎
  • Year and Date: 2015-11-12
• [Presentation] 不適切な養育を受けた児童の Cortisol・Oxytocin 値にみる生体反応 の相違 (2015)
  • Author(s): 水島栄、藤澤隆史、滝口慎一郎、 熊崎博一、田仲志保、友田明美
  • Organizer: 第56 回日本児童青年 精神医学会総会
  • Place of Presentation: 横浜市, パシフィコ横浜
  • Year and Date: 2015-09-29
• [Presentation] 虐待環境からの隔離によるネガティ ブ表情読み取り能力の変化 (2015)
  • Author(s): 小泉径子、熊崎博一、滝口慎一郎、 友田明美、小坂浩隆
  • Organizer: 第56 回日本児童青年 精神医学会総会
  • Place of Presentation: 横浜市, パシフィコ横浜
  • Year and Date: 2015-09-29
• [Presentation] Low Striatal Activity during Reward Perception Caused by Childhood Adversity. (2015)
  • Author(s): Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Kumazaki H, Koizumi M, Shimada K, Okamoto Y, Jung M, Kosaka H, Tomoda A
  • Organizer: 第57回日本小児神経学会総会
  • Place of Presentation: 大阪市, 帝国ホテル大阪
  • Year and Date: 2015-05-28
• [Presentation] Reward Sensitivity Dysfunction in children and adolescents with Reactive Attachment Disorder (2015)
  • Author(s): Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Kumazaki H, Koizumi M, Jung M, Kosaka H, Tomoda A
  • Organizer: The 13th Asian and Oceania Congress of Child Neurology AOCCN 2015
  • Place of Presentation: Taipei, Taipei International Convention Center
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Book] Memory in Social Context: Brain, Mind, and Society. Structural and functional changes of brain due to childhood maltreatment and adversity (2018)
  • Author(s): Tomoda A, Takiguchi S, Shimada K, Fujisawa TX
  • Publisher: Springer
• [Book] 障がい児・者の手術室看護マニュアル 19章 被虐待児 (2018)
  • Author(s): 友田明美，重見研司，白石裕子，滝口慎一郎
  • Publisher: 金芳堂
• [Book] 日本臨牀 76(4) ADHDの脳機能 (2018)
  • Author(s): 水野賀史，島田浩二，滝口慎一郎，友田明美
  • Publisher: 日本臨牀社
• [Book] 福井大学病院の得意な治療がわかる本 愛着障害の最新治療 (2017)
  • Author(s): 滝口慎一郎，友田明美
  • Publisher: バリューメディカル
• [Book] 臨床精神薬理 20(6) 今後開発が期待される注意欠如・多動症の治療薬 (2017)
  • Author(s): 滝口慎一郎，友田明美
  • Publisher: 星和書店
• [Book] 今日の治療指針 2017年版（私はこう治療している）被虐待児症候群 (2017)
  • Author(s): 滝口慎一郎
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 発達145「子どものトラウマのケアとレジリエンス」子どものトラウマとは (2016)
  • Author(s): 友田明美 滝口慎一郎
  • Total Pages: 6
  • Publisher: ミネルヴァ書房
• [Book] 小児内科 特集「子ども虐待」子ども虐待の脳科学研究 (2016)
  • Author(s): 島田浩二，滝口慎一郎，藤澤隆史，友田明美
  • Total Pages: 5
  • Publisher: 東京医学社