Research Project
Grant-in-Aid for Young Scientists (B)
To elucidate the food-intake dependent relationship between lipid absorption and gut immunology, we developed the mesenteric lymph cannulated rat model. The all experiment was carried out under continuous isoflurane anesthesia. The lymph was collected from one hour before the administration of food sample (distilled water or cocoa butter) to four hours later of the administration. The lymph flow was increased in a short period after the administration of distilled water, however in the case of cocoa butter, it was increased 3-4hr later of the administration. It was not observed a big change in the ratio of T cell and B cell of the collected lymph. Interestingly, the IL-22 concentration of the collected lymph was 10 to 20 times higher than that of serum plasma. To elucidate the significance of IL-22 concentration in the lymph, further experiment will be needed.
All 2017 2016 2015
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 2 results, Open Access: 1 results) Presentation (1 results)
実験医学
Volume: 35 Pages: 403-408
Aging Cell
Volume: 14（4） Issue: 4 Pages: 582-594
10.1111/acel.12330
120007100161
Lymphatic Res Biol
Volume: 13(3) Issue: 3 Pages: 202-207
10.1089/lrb.2015.0017
