Synthesis of new chiral pyridines and efforts of their application to catalytic C(SP3)-H bond functionalization
| Project/Area Number |
15K21046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
Chemical pharmacy
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Research Collaborator |
YODA Hidemi 静岡大学, 工学部, 教授 (20201072)
TAKAHASHI Masaki 静岡大学, 工学部, 教授 (30313935)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | テトラミン酸 / ピリジン誘導体 / 光学活性 / ビピリジン / C2-ピリジン |
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| Outline of Final Research Achievements |
We have developed new synthetic methodology for enantiopure C2-symmetric and unsymmetric lactam-fused pyridines. A key outcome of this work is citric acid-promoted cyclisation of benzylidene tetramic acids and various enamines, leading to the relevant pyridines in enantiomerically pure forms. Additionally, we have been investigating their application in catalytic C(sp3)-H bond functionalization. Chiral bipyidine reagent was found to promote palladium-catalyzed reaction to give the product in excellent yield, albeit with low enantioselectivity.
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Report
(4 results)
Research Products
(55 results)
