| Project/Area Number |
15K21054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
Tumor biology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 家族性胃がん / 若年性胃がん / 網羅的染色体コピー数解析 / 生殖細胞系列コピー数変化 / CDH1 / CytoScan HD Array / 生殖細胞 / コピー数変化 |
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| Outline of Final Research Achievements |
Comprehensive copy number analysis was performed for familial and early onset gastric cancer patients and relatives who were negative for germline mutations and copy number alterations in the CDH1 gene. In each family, 10 to 60 regions were detected as copy number variation (CNV) that may be involved in gastric carcinogenesis. CNVs of cancer-related gene were selected and investigated in healthy volunteers. CNVs of several apoptosis-related genes were revealed to cause in familial and early onset gastric cancer patients. This study was suggested that genes other than CDH1 gene were also involved in gastric carcinogenesis.
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