Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Outline of Final Research Achievements |
We identified ephB2 receptor as SSB4 (SPSB4)-interacting protein. SPSB4 is a functionally unknown ubiquitin ligase.EphB2 is known to act as oncogene or tumuor suppressor depending on the cell type. We showed that SPSB4 destabilized EphB2 cytoplasmic domain. Next, we analyzed cell repulsive responses by co-culturing ephrin B2-expressing cells and EphB2-expressing cells.As a result, SPSB4 knock down enhanced cell repulsive responses and SPSB4 was shown to prevent EphB2 signaling pathway.
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