Three-dimensional printer-generated patient-specific phantom for artificial in-vivo dosimetry in radiotherapy quality assurance

• Project/Area Number: 15K21060
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology; Radiation science
• Research Institution: Nagoya University
• Principal Investigator: KAMOMAE Takeshi 名古屋大学, 医学部附属病院, 病院助教 (60706282)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 放射線治療 / 品質管理 / 3Dプリンタ / 三次元積層造形 / 個別化医療 / 三次元造形 / 患者個別 / 線量計測 / 医学物理学 / 患者模擬ファントム / 3次元造形

Outline of Final Research Achievements

Pretreatment patient-specific quality assurance for radiotherapy is performed by measurement using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we constructed a system for generating patient-specific three-dimensional (3D)-printed phantoms based on the patient computed tomography data sets. The results of this study demonstrated the feasibility of the 3D-printed phantom for artificial in-vivo dosimetry in radiotherapy quality assurance. This developed method will be the remarkable progress of the advanced dosimetry in radiotherapy and contribute to establishment and promotion of the precision and personalized radiotherapy treatment.

Research Products

• [Journal Article] A novel radiation protection device based on tungsten functional paper for application in interventional radiology. (2017)
  • Author(s): Monzen H, Tamura M, Shimomura K, Onishi Y, Nakayama S, Fujimoto T, Matsumoto K, Hanaoka K, Kamomae T.
  • Journal Title: J Appl Clin Med Phys. Volume: 18(3) Issue: 3 Pages: 215-220
  • DOI: 10.1002/acm2.12083
  • Peer Reviewed / Open Access
• [Journal Article] Influence of multi-leaf collimator leaf transmission on head and neck intensity-modulated radiation therapy and volumetric-modulated arc therapy planning (2017)
  • Author(s): Sasaki Motoharu、Tominaga Masahide、Kamomae Takeshi、Ikushima Hitoshi、Kitaoka Motonori、Bando Ryota、Sakuragawa Kanako、Oita Masataka
  • Journal Title: Japanese Journal of Radiology Volume: 35 Issue: 9 Pages: 511-525
  • DOI: 10.1007/s11604-017-0661-8
  • NAID: 50012661035
  • Peer Reviewed / Open Access
• [Journal Article] Clinical usefulness of MLCs in robotic radiosurgery systems for prostate SBRT (2017)
  • Author(s): Tomida Masashi、Kamomae Takeshi、Suzuki Junji、Ohashi Yoichi、Itoh Yoshiyuki、Oguchi Hiroshi、Okuda Takahito
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 18 Issue: 5 Pages: 124-133
  • DOI: 10.1002/acm2.12128
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance (2017)
  • Author(s): Kamomae Takeshi、Shimizu Hidetoshi、Nakaya Takayoshi、Okudaira Kuniyasu、Aoyama Takahiro、Oguchi Hiroshi、Komori Masataka、Kawamura Mariko、Ohtakara Kazuhiro、Monzen Hajime、Itoh Yoshiyuki、Naganawa Shinji
  • Journal Title: Physica Medica Volume: 44 Pages: 205-211
  • DOI: 10.1016/j.ejmp.2017.10.005
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric feasibility of using tungsten-based functional paper for flexible chest wall protectors in intraoperative electron radiotherapy for breast cancer (2017)
  • Author(s): Kamomae Takeshi、Monzen Hajime、Kawamura Mariko、Okudaira Kuniyasu、Nakaya Takayoshi、Mukoyama Takashi、Miyake Yoshikazu、Ishihara Yoshitomo、Itoh Yoshiyuki、Naganawa Shinji
  • Journal Title: Phys Med Biol. Volume: 63 Issue: 1 Pages: 015006-015006
  • DOI: 10.1088/1361-6560/aa96cf
  • NAID: 120006473526
  • Peer Reviewed
• [Journal Article] Characterization of stochastic noise and post-irradiation density growth for reflective-type radiochromic film in therapeutic photon beam dosimetry. (2016)
  • Author(s): Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Hiroshi Oguchi, Mariko Kawamura, Hajime Monzen, Yoshiyuki Itoh, Shiniji Naganawa
  • Journal Title: Phys Med. Volume: 32 Issue: 10 Pages: 1314-1320
  • DOI: 10.1016/j.ejmp.2016.07.091
  • Peer Reviewed / Open Access
• [Journal Article] Late Rectal Toxicity from Image-guided Intensity Modulated Radiotherapy for Prostate Cancer (2016)
  • Author(s): Sayo Maki, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Mariko Kawamura, Takeshi Kamomae, Shinji Naganawa, Yasushi Yoshio, Momokazu Gotoh, Mitsuru Ikeda
  • Journal Title: Anticancer Research Volume: 36 (6) Pages: 2967-2973
  • Peer Reviewed
• [Journal Article] Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer (2016)
  • Author(s): Masashi Tomida, Kuniyasu Okudaira, Takeshi Kamomae, Hiroshi Oguchi, Yoshikazu Miyake, Kazuo Yoneda, Yoshiyuki Itoh
  • Journal Title: Nagoya Journal of Medical Science Volume: 78 (3) Pages: 313-321
  • NAID: 120005837933
  • Peer Reviewed
• [Journal Article] Dosimetric impact of dental metallic crown on intensity-modulated radiotherapy and volumetric-modulated arc therapy for head and neck cancer (2016)
  • Author(s): Takeshi Kamomae, Yoshiyuki Itoh, Kuniyasu Okudaira, Takayoshi Nakaya, Masashi Tomida, Yoshikazu Miyake, Hiroshi Oguchi, Takehiro Shiinoki, Mariko Kawamura, Noriyuki Yamamoto, Shinji Naganawa
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 17 Issue: 1 Pages: 234-245
  • DOI: 10.1120/jacmp.v17i1.5870
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparison of Dose Accuracy between Film and Two-dimensional Detectors in Intensity-modulated Radiation Therapy (2015)
  • Author(s): Yuichi Onishi, Shinichi Nakayama, Shinsaku Watanabe, Souichirou Kaneshige, Hajime Monzen, Kenji Matsumoto, Naoya Shintani, Takeshi Kamomae
  • Journal Title: Journal of the Korean Physical Society Volume: 67 Issue: 1 Pages: 89-95
  • DOI: 10.3938/jkps.67.89
  • Peer Reviewed
• [Presentation] A new shield for intra operative electron radiotherapy (IOERT) of early breast cancer (2017)
  • Author(s): Mariko Kawamura, Takeshi Kamomae, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Kana Kimura, Yuka Kozai, Yumi Oie, Yuki Takase, Shinji Naganawa
  • Organizer: The 2nd Meeting of Federation of Asisan Organizations for Radiation Oncology (FARO)
  • Int'l Joint Research
• [Presentation] MRI-visible phantom fabricated using material jetting three-dimensional printing with nanocomposite hydrogel for MRI-guided therapy simulation (2017)
  • Author(s): Takeshi Kamomae, Tomohiro Komada, Yutaka Kato, Kuniyasu Okudaira, Takashi Matsumura, Yoshihiro Norikane, Tatsuya Niimi, Yoshiyuki Itoh, Shinji Naganawa
  • Organizer: 8th Japan-Korea Joint Meeting on Medical Physics
  • Int'l Joint Research
• [Presentation] Characterization of stochastic noise and post-irradiation density growth for GAFCHROMIC EBT-XD films in therapeutic photon beam dosimetry (2017)
  • Author(s): Yuichi Onishi, Hajime Monzen, Takeshi Kamomae, Shinichi Nakayama, Yutako Oyama, Hirofumi Enomoto, Miharu Oshima, Ayako Mori
  • Organizer: 8th Japan-Korea Joint Meeting on Medical Physics
  • Int'l Joint Research
• [Presentation] 3Dプリンタの医用応用と放射線治療品質管理への利用に向けて (2017)
  • Author(s): 加茂前 健
  • Organizer: 東海放射線腫瘍研究会第45回技術部会
  • Invited
• [Presentation] An attempt to create a blood vessel model by 3D printer using a hydrogel (2017)
  • Author(s): Tomohiro Komada, Takeshi Kamomae, Jun Ito, Hiroyasu Umakoshi, Ken Nagasaka, Masaya Matsushima, Kojiro Suzuki, Makoto Tsuduki, Takeshi Uemura, Takashi Matsumura, Yoshihiro Norikane, Tatsuya Niimi, Shinji Naganawa
  • Organizer: 第46回日本IVR学会総会
• [Presentation] A sensitivity calibration of radiophotoluminescent glass dosimeter for scattered therapeutic x-ray in water equivalent phantom (2017)
  • Author(s): Shouichi Yokose, Masataka Komori, Takeshi Kamomae, Hidetoshi. Shimizu, Kuniyasu Okudaira, Fumiaki Kawabata, Hiroshi Oguchi
  • Organizer: 第113回日本医学物理学術大会
• [Presentation] 放射線治療分野における3Dプリンタの活用 (2017)
  • Author(s): 加茂前 健
  • Organizer: 平成28年度東北大学医学物理セミナー
  • Int'l Joint Research
• [Presentation] Development of a patient-specific QA system by three-dimensional printing technique (2016)
  • Author(s): Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Takashi Mukouyama, Kuniyasu Okudaira, Yoshikazu Miyake, Masataka Komori, Hiroshi Oguchi, Yoshiyuki Itoh, Shinji Naganawa
  • Organizer: 22nd International Conference on Medical Physics
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] CLINICAL ADVANTAGES OF A ROBOTIC RADIOSURGERY SYSTEM EQUIPPED WITH A MULTI-LEAF COLLIMATOR IN PROSTATE STEREOTACTIC BODY RADIATION THERAPY (2016)
  • Author(s): Masashi Tomida, Junji Suzuki, Hironori Takahashi, Kyohei Hamajima, Takeshi Kamomae, Yoichi Ohashi, Hiroshi Oguchi, Takahito Okuda
  • Organizer: 22nd International Conference on Medical Physics
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] MAGICゲル線量計の容器サイズに起因する感度変化の補正 (2016)
  • Author(s): 小島優芽, 田淵麻香, 小口 宏, 奥平訓康, 加茂前健, 櫻井康雄, 小森雅孝
  • Organizer: 第5回3次元ゲル線量計研究会
  • Place of Presentation: 京都大学宇治キャンパス（京都府宇治市）
  • Year and Date: 2016-12-03
• [Presentation] 名古屋大学におけるMAGICゲル線量計のR2値の変動 (2016)
  • Author(s): 田中沙弥, 小島優芽, 田淵麻香, 小口 宏, 奥平訓康, 櫻井康雄, 加茂前健, 小森雅孝
  • Organizer: 第5回 3次元ゲル線量計研究会
  • Place of Presentation: 京都大学宇治キャンパス（京都府宇治市）
  • Year and Date: 2016-12-03
• [Presentation] 甲状腺機能亢進症の131I内用療法における吸収線量測定の基礎的検討 (2016)
  • Author(s): 柳 秀輝, 阿部真治, 藤田尚利, 櫻木庸博, 加茂前健, 清水秀年, 小森雅孝, 小芝有美子, 本田将之, 国本啓太, 加藤克彦
  • Organizer: 第36回日本核医学技術学会総会学術大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2016-11-03
• [Presentation] Development of a patient-specific QA system by three-dimensional printing technique (2016)
  • Author(s): Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Takashi Mukouyama, Kuniyasu Okudaira, Yoshikazu Miyake, Masataka Komori, Hiroshi Oguchi, Yoshiyuki Itoh, Shinji Naganawa
  • Organizer: 第112回日本医学物理学会学術大会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市）
  • Year and Date: 2016-10-08
• [Presentation] Dose Impact of Rectal Gas on Prostate VMAT (2016)
  • Author(s): Motoharu Sasaki, Hitoshi Ikushima, Masahide Tominaga, Tetsuya Kawashita, Takeshi Kamomae, Ryota Bando, Kanako Sakuragawa, Masataka Oita.
  • Organizer: 2016 AAPM Annual Meeting
  • Place of Presentation: Washington, D.C. (USA)
  • Year and Date: 2016-07-31
  • Int'l Joint Research
• [Presentation] The influence of container size on polymer gel dosimetry (2016)
  • Author(s): Yume Kojima, Takayuki Miyachi, Hiroshi Oguchi, Kuniyasu Okudaira, Takeshi Kamomae, Yasuo Sakurai, Masataka Komori
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
• [Presentation] PHITSを用いた放射線治療用電子線に対する金属粉含有機能紙の遮蔽性能評価 (2016)
  • Author(s): 加茂前健, 門前一, 川村麻里子, 奥平訓康, 中谷隆佳, 向山隆史, 末澤正太郎, 川端文隆, 杉田和真, 三宅良和, 小口宏, 伊藤善之, 長縄慎二
  • Organizer: PHITS研究会
  • Place of Presentation: TKP熱海研修センター（静岡県熱海市）
• [Presentation] CTによるポリマーゲル線量計の信号取得 (2015)
  • Author(s): 宮地貴之, 小島優芽, 小口宏, 奥平訓康, 堤貴紀, 加茂前健, 小森雅孝
  • Organizer: 第4回3Dゲル線量計研究会
  • Place of Presentation: 帝京大学（東京都板橋区）
  • Year and Date: 2015-11-28
• [Presentation] MAGICゲル線量計の有用性の総合評価 (2015)
  • Author(s): 田中文野, 宮地貴之, 小島優芽, 小口宏, 奥平訓康, 櫻井康雄, 加茂前健, 小森雅孝
  • Organizer: 第4回3Dゲル線量計研究会
  • Place of Presentation: 帝京大学（東京都板橋区）
  • Year and Date: 2015-11-28
• [Presentation] カラギーナンを用いたMAG系ゲル線量計の基礎的検討 (2015)
  • Author(s): 田淵麻香, 宮地貴之, 小島優芽, 小口宏, 奥平訓康, 櫻井康雄, 加茂前健, 小森雅孝
  • Organizer: 第4回3Dゲル線量計研究会
  • Place of Presentation: 帝京大学（東京都板橋区）
  • Year and Date: 2015-11-28
• [Presentation] ポリマーゲル線量計での算出線量に対する容器サイズの影響 (2015)
  • Author(s): 小島優芽, 宮地貴之, 小口 宏, 奥平訓康, 加茂前健, 櫻井康雄, 小森雅孝
  • Organizer: 第4回3Dゲル線量計研究会
  • Place of Presentation: 帝京大学（東京都板橋区）
  • Year and Date: 2015-11-28
• [Presentation] Characterization of Stochastic Noise and Post-Exposure Density Growth for Reflective-Type Radiochromic Film in Therapeutic Photon Beam Dosimetry (2015)
  • Author(s): Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Yoshiyuki Itoh, and Shinji Naganawa
  • Organizer: 15th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: 西安（中華人民共和国）
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Double-energy CT scanによる陽子線阻止能比の算出 (2015)
  • Author(s): 下小牧遼太, 小森雅孝, 大町千尋, 柴田洋希, 歳藤利行, 加茂前健, 小口宏
  • Organizer: 第43回日本放射線技術学会秋季学術大会
  • Place of Presentation: 金沢市文化ホール（石川県金沢市）
  • Year and Date: 2015-10-08
• [Presentation] Dual energy CTを利用したポリマーゲル線量計の信号取得の評価 (2015)
  • Author(s): 宮地貴之, 小島優芽, 小口宏, 奥平訓康, 加茂前健, 堤貴紀, 小森雅孝
  • Organizer: 第43回日本放射線技術学会秋季学術大会
  • Place of Presentation: 金沢市文化ホール（石川県金沢市）
  • Year and Date: 2015-10-08
• [Presentation] Evaluation of Tungsten-Based Functional Paper for Attenuation Device in Intraoperative Radiotherapy for Breast Cancer (2015)
  • Author(s): Takeshi Kamomae, Hajime Monzen, Kuniyasu Okudaira, Yoshikazu Miyake, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Yoshiyuki Itoh, Toyone Kikumori, Shinji Naganawa
  • Organizer: 2015 AAPM Annual Meeting
  • Place of Presentation: Anaheim（アメリカ合衆国）
  • Year and Date: 2015-07-12
  • Int'l Joint Research
• [Remarks] 名古屋大学学術機関リポジトリ
  • URL: http://hdl.handle.net/2237/27925