| Project/Area Number |
15K21065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Developmental biology
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| Research Institution | Nagoya University |
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Principal Investigator |
Shindo Asako 名古屋大学, 理学研究科, 助教 (60512118)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 組織形態形成 / アクトミオシン / アフリカツメガエル / 形態形成 / 収斂伸長運動 / 平面内細胞極性経路 / 細胞骨格 |
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| Outline of Final Research Achievements |
Convergent extension is a ubiquitous process of collective cell movement that elongates the tissue axis in developing animals. It is still unknown how the multiple cells are coordinately regulated to achieve the right shape of tissue. In this study, we performed the 4D imaging of actomyosin in Xenopus laevis mesoderm, and show that the actomyosin oscillations are asynchronous between neighboring cells during the cells move. We also found that such asynchrony is essential to elongate the tissue properly, and the regulatory molecules, which relate to human congenital disease, control the temporal pattern of the actomyosin oscillation. Our study provides new insight into the function and control of actomyosin in the tissue formation.
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