Analysis of the relationship between an accumulation of mutant mtDNA and the mitochondrial quality control in Parkinsonism
Project/Area Number |
15K21081
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
Laboratory animal science
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
Fuke Satoshi 滋賀医科大学, 医学部, 助教 (20422660)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ミトコンドリア / パーキンソン病 / ミトコンドリアDNA / Parkin / Polg / mitochondria / mtDNA |
Outline of Final Research Achievements |
To elucidate the physiological significance of relationships between an accumulation of mutant mtDNA molecules and the mitochondrial quality control depending on mitophagy in Parkinson’s disease, a role of mitophagy due to Parkin in mtDNA dynamics was assessed. In a mouse neuroblastoma cell line (Neuro2a), we found that there are not a few Parkin-nonlocalized mitochondria that were undegraded after the induction of mitophagy by FCCP mitochondrial depolarizing agent. These result suggest that the mitochondrial depolarization is necessary but not enough for the removal of damaged mitochondria through mitophagy.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder2016
Author(s)
Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: -
Issue: 8
Pages: 518-529
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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