Research Project
Grant-in-Aid for Young Scientists (B)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease characterized by adrenergically mediated ventricular tachyarrhythmias that cause sudden cardiac death. We identified a novel TRPM4 mutation in a five-year-old boy with CPVT. Electrophysiological analysis revealed small TRPM4 currents at a calcium concentration of 10μM in spite of no significant current changes at a lower concentration of 1μM. Western blotting analysis showed no significant difference in plasma membrane expression between normal and mutant TRPM4 channels. These results indicate that the effect of the TRPM4 mutation is related to calcium sensitivity.
