Investigation of cancer specific survival system via LAT1/4F2hc-integrin complex
| Project/Area Number |
15K21133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
Kaneda Kazuko 大阪大学, 理学研究科, 特任助教(常勤) (00533209)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アミノ酸トランスポーター / インテグリン / 栄養制御 |
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| Outline of Final Research Achievements |
LAT1 (L-type amino acid transporter 1) is a system L amino acid transporter that transports large neutral amino acids in a sodium independent manner, and correlation between its high expression and poor prognosis in various cancer types has been reported. It is clear that nutritional control via LAT1 is essential for cancer cell survival. On the other hand, integrins are molecules that play an important role in cancer development and metastasis. It is known that LAT1 forms a complex with integrin, but its conjugate relationship is still unknown. In this study, the expression of LAT1 was regulated by cancer cell-specific nutritional control. Expression levels of integrin are inhibit by LAT1 inhibition. LAT1 inhibition also decrease survival rate and growth speed of cancer cells. From these results, this study suggested that extracellular nutritional environment is one of the factors in conversion from normal cells to cancer cells.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype.2015
Author(s)
Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T.
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Journal Title
J Virol.
Volume: 89
Issue: 17
Pages: 9080-9
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] LAT1阻害薬の抗がん剤耐性株への効果の検討.2016
Author(s)
兼田（中島）加珠子, 陳 映安, 伊藤万理子, Quan Lili, Ling Wei, Pornparn Kongpracha, 大垣 隆一, 永森 收志, 金井 好克.
Organizer
第11回トランスポーター研究会年会
Place of Presentation
京都大学 宇治キャンパスきはだホール
Year and Date
2016-07-02
Related Report
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