| Project/Area Number |
15K21134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
Neurophysiology / General neuroscience
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| Research Institution | Osaka University |
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Principal Investigator |
Ohkawa Toshika 大阪大学, 医学系研究科, 招へい教員 (90418880)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脊髄損傷 / 軸索ガイダンス / 嗅粘膜移植術 / ホスホリパーゼ / リゾリン脂質 / リピドミクス |
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| Outline of Final Research Achievements |
We conducted the clinical study of olfactory mucosa autografts (OMA) for chronic spinal cord injury (SCI). In this study, we investigated the new axonal extension method in OMA. Calcium-independent phospholipase A2β(iPLA2β) which PLA2G6 gene encodes plays an important role in remodeling of membrane phospholipids. The spinal cord injury models of PLA2G6 knockout mice revealed that iPLA2β could exacerbate demyelination and inflammation after SCI. Using the inhibitor or the antibody of iPLA2β, there is a possibility that we may reduce demyelination and inflammation after the injury of normal spinal cord in OMA surgery. As a result, we may promote the axonal extension after OMA.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性期完全脊髄損傷に対する自家嗅粘膜移植術による随意筋の下肢筋電図の出現や体幹支持性の向上には非常に長期のリハビリ期間を要している。本研究により、嗅粘膜移植術にiPLA2βの阻害剤あるいは抗体を付加することで、術後のリハビリ機関の短縮および神経機能改善の向上を期待できる。また、iPLA2βは膜リン脂質のリモデリングに重要な役割を果たしており、iPLA2βを用いた脊髄損傷の基礎研究により2次損傷増悪機構の病態解明につながることが期待できる。
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