Animal model study for mechanisms of central poststroke pain and pain relieving effect with neurostimulation
| Project/Area Number |
15K21142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Hosomi Koichi 大阪大学, 医学系研究科, 特任講師(常勤) (70533800)
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| Research Collaborator |
SAITOH Youichi
OKADA Kenichi
KADONO Yoshinori
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 中枢性脳卒中後疼痛 / 動物疾患モデル / 視床痛 / 一次運動野刺激 / ニューロモデュレーション / 安静時fMRI / 反復経頭蓋磁気刺激 / 安静時機能的MRI |
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| Outline of Final Research Achievements |
We created a macaque model of central poststroke pain (CPSP), and investigated its behavior and brain function using a high magnetic field MRI. Functional connectivities between pain related brain regions increased after pain development. Primary motor cortex stimulation using repetitive transcranial magnetic stimulation (rTMS) alleviated hyperesthesia, and decreased functional connectivities between pain related brain regions. The findings from this study have suggested that the functional connectivity between pain related brain regions is involved in mechanisms of CPSP development and pain relief after rTMS.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Daily repetitive transcranial magnetic stimulation for post-stroke upper limb paresis in the subacute period2016
Author(s)
Hosomi K, Morris S, Sakamoto T, Taguchi J, Maruo T, Kageyama Y, Kinoshita Y, Goto Y, Shimokawa T, Koyama T, Saitoh Y
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 25(7)
Issue: 7
Pages: 1655-64
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] MAGNETOENCEPHALOGRAPHIC-BASED BRAIN-MACHINE INTERFACE ROBOTIC HAND FOR CONTROLLING SENSORIMOTOR CORTICAL PLASTICITY AND PHANTOM LIMB PAIN2017
Author(s)
Takufumi Yanagisawa,Ryohei Fukuma,BenSeymour,Kouichi Hosom,Haruhiko Kishima,HiroshiYokoi,Masayuki Hiata, Toshiki Yoshimine,Yukiyasu Kamitani,Youichi Saitoh,
Organizer
The 16th European Congress of Clinical Neurophysiology ECCN 2017
Related Report
Int'l Joint Research
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