Verification of the accuracy of intraoperative MRS using metabolomic analysis

• Project/Area Number: 15K21146
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery; Basic / Social brain science
• Research Institution: Kobe University
• Principal Investigator: KOHTA MASAAKI 神戸大学, 医学研究科, 助教 (80590843)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 術中MRI / 術中MRスペクトロスコピー / 神経膠腫 / 術中MRS

Outline of Final Research Achievements

The present study demonstrated that intraoperative MRS was a useful tool to evaluate the proliferative activity of residual tumor during glioma surgery. The cutoff value of choline and choline/NAA may provide a good guide for the practical use of glioma surgery. On the other hand, there was no significant linear correlation between intraoperative MRS and GC-MS.

Research Products

• [Presentation] グリオーマ手術における術中MRSの現状と近未来 (2017)
  • Author(s): 甲田 将章、篠山 隆司、前山 昌博、水川 克、甲村 英二
  • Organizer: 第17回日本術中画像情報学会
  • Place of Presentation: 鹿児島
• [Presentation] グリオーマ手術における術中MRSの有用性に関する検討 (2016)
  • Author(s): 甲田 将章、篠山 隆司、長島 宏明、前山 昌博、水川 克、甲村 英二
  • Organizer: 日本脳神経外科学会 第75回学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-29
• [Presentation] Intraoperative magnetic resonance spectroscopy for glioma surgery (2016)
  • Author(s): Takashi Sasayama, Masaaki Kohta, Kazuhiro Tanaka, Katsu Mizukawa, Hiroaki Nagashima, Tomoaki Nakai, Junichi Sakata, Masahiro Maeyama, Eiji Kohmura
  • Organizer: 13th Asian Society for Neuro-Oncology (ASNO) Meeting
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2016-09-11
  • Int'l Joint Research
• [Presentation] グリオーマ手術における術中MRSの有用性に関する検討 (2016)
  • Author(s): 甲田 将章、篠山 隆司、長嶋 宏明、水川 克、甲村 英二
  • Organizer: 第16回日本術中画像情報学会
  • Place of Presentation: 愛媛