| Project/Area Number |
15K21153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
SAKAKIBARA SHUNSUKE 神戸大学, 医学研究科, 客員准教授 (50444592)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 光受容 / メラノーマ / メラノサイト / メラノプシン |
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| Outline of Final Research Achievements |
The malignant melanoma is one of the high malignancy tumor occurring on skin. So far, we have shown that a cell of the skin received light from the outside environment through photoreceptor protein. Similarly, photoreceptor protein might be expressed in a melanoma cell and considered the possibility of the control of the cell proliferation by the light irradiation. In this study, we had cleared the following; (1) melanocyte and a melanoma cells express photoreceptor protein, malanopsin, (2) G protein as a second messenger is co-expressed with melanopsin, (3 )Blue light irradiation influenced cytosolic calcium uptake.
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