| Project/Area Number |
15K21154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
TOH RYUJI 神戸大学, 医学研究科, 特命准教授 (50379418)
ISHIDA TATSUEO 神戸大学, 医学研究科, 特命教授 (00379413)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血栓 / トランス脂肪酸 |
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| Outline of Final Research Achievements |
(1) Five percent of elaidic acid treatment increased the serum concentration of elaidic acid at almost 100-fold. This indicates oral elaidic acid treatment actually increase the circulating elaidic acid level and incorporated into the organs in mice.
(2) Afte the 4 weeks of treatment of elaidic acid or oleic acis as a control, we performed IVC ligation to induce deep venous thrombosis. Unfortunately, 6 mice died after the operation. We did not observe statistical significance, but there maybe a tendency that elaidic acid augments the DVT formation. We therefore add 10 more mice to have final conclusion.
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