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Implantable optical diagnostic and therapeutic devices based on biophotonic LSI technology

Research Project

Project/Area Number 15K21164
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanobioscience
Electron device/Electronic equipment
Research InstitutionThe University of Tokyo (2016-2018)
Nara Institute of Science and Technology (2015)

Principal Investigator

Takehara Hiroaki  東京大学, 大学院工学系研究科(工学部), 助教 (60723088)

Research Collaborator Ohta Jun  
Tokuda Takashi  
Sasagawa Kiyotaka  
Noda Toshihiko  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords体内埋植デバイス / 半導体集積回路 / ハイドロゲル材料 / 細胞応答 / バイオデバイス / 埋め込みデバイス / フレキシブルデバイス / 光導波路 / 光半導体デバイス / 光治療 / 蛍光イメージング
Outline of Final Research Achievements

In this research, a novel method for optical diagnosis and therapy based on the integration between biocompatible polymer materials and large-scale integration (LSI) chip technology was proposed. Implantable optical theranostic devices and implantable optical waveguides enabled regional illumination inside the body and contact imaging of biological tissues for optical diagnosis and therapy.

Academic Significance and Societal Importance of the Research Achievements

光を用いて診断・治療を一体化する新たな医療技術が注目されている。本研究で確立した生体内光センシング・光治療一体化デバイス技術は、生体と親和して生体内で光を操作する手法を提供し、光を利用するバイオメディカルデバイス技術の発展に貢献する。また、半導体デバイス研究分野において本研究は、医療応用を指向した体内埋植型集積回路センサ技術という新たな応用分野の開拓に資する。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 6 results) Presentation (15 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results)

  • [Journal Article] Mechanical strength evaluation of crystalline poly (L-lactic acid) fabricated by replica micromolding for bioabsorbable microneedle devices2019

    • Author(s)
      Yukihiro Kanda, Hiroaki Takehara, and Takanori Ichiki
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 印刷中

    • NAID

      210000156073

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma-assisted electrospray deposition of thin elastomer films2019

    • Author(s)
      Kohei Hashimoto, Hiroaki Takehara, and Takanori Ichiki
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 印刷中

    • NAID

      210000156074

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-chip cell analysis platform: Implementation of contact fluorescence microscopy in microfluidic chips2017

    • Author(s)
      Takehara Hiroaki、Kazutaka Osawa、Haruta Makito、Noda Toshihiko、Sasagawa Kiyotaka、Tokuda Takashi、Ohta Jun
    • Journal Title

      API Advances

      Volume: 7 Issue: 9 Pages: 095213-095213

    • DOI

      10.1063/1.4986872

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation2017

    • Author(s)
      Makito Haruta,Naoya Kamiyama,Shun Nakajima,Mayumi Motoyama,Mamiko Kawahara Yasumi Ohta,Atsushi Yamasaki,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Yasuyuki Ishikawa,Takashi Tokuda,Hitoshi Hashimoto,Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 5 Pages: 057001-057001

    • DOI

      10.7567/jjap.56.057001

    • NAID

      210000147741

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Implantable microsized image sensor for data transmission with intravital optical communication2016

    • Author(s)
      Hiroaki Takehara,Hajime Hayami,Kengo Nagata,Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa,Takashi Tokuda,Jun Ohta
    • Journal Title

      The Journal of Engineering

      Volume: - Issue: 1 Pages: 1-3

    • DOI

      10.1049/joe.2016.0311

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In-vitro long-term performance evaluation and improvement in the response time of CMOS-based implantable glucose sensors2016

    • Author(s)
      T. Tokuda, T. Kawamura, K. Masuda, T. Hirai, Hironari Takehara, Y. Ohta, M. Motoyaa, Hiroaki Takehara, T. Noda, K. Sasagawa, T. Okitsu, S. Takeuchi, and J. Ohta
    • Journal Title

      IEEE Design & Test

      Volume: 33 Issue: 4 Pages: 37-48

    • DOI

      10.1109/mdat.2016.2560137

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ZnO Nanorod Arrays Fabricated by Hydrothermal Method Using Different Thicknesses of Seed Layer for Applications in Hybrid Photovoltaic Cells2016

    • Author(s)
      Anek Wuthayavanich, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Sensors and Materials

      Volume: 28 Pages: 1

    • DOI

      10.18494/SAM.2016.1293

    • ISSN
      0914-4935, 2435-0869
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Implantable micro-optical semiconductor devices for optical theranostics in deep tissue2016

    • Author(s)
      Hiroaki Takehara, Yuji Katsuragi, Yasumi Ohta, Mayumi Motoyama, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Applied Physics Express

      Volume: 9 Issue: 4 Pages: 047001-047001

    • DOI

      10.7567/apex.9.047001

    • NAID

      210000137867

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Implantable self-reset CMOS image sensor and its application to hemodynamic response detection in living mouse brain2016

    • Author(s)
      Takahiro Yamaguchi, Hiroaki Takehara, Yoshinori Sunaga, Makito Haruta, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 4S Pages: 04EM02-04EM02

    • DOI

      10.7567/jjap.55.04em02

    • NAID

      210000146393

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Wireless image-data transmission from an implanted image sensor through a living mouse brain by intra body communication2016

    • Author(s)
      Hajime Hayami, Hiroaki Takehara, Kengo Nagata, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 4S Pages: 04EM03-04EM03

    • DOI

      10.7567/jjap.55.04em03

    • NAID

      210000146394

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Micromolding Process for Bioabsorbable Poly L-Lactic Acid (PLLA) using Polydimethylsiloxane (PDMS) Replica Mold2018

    • Author(s)
      Hiroaki Takehara, Yukihiro Kanda, Yuki Hadano, and Takanori Ichiki
    • Organizer
      The 31th International Microprocesses and Nanotechnology Conference (MNC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrospray deposition assisted with corona discharge for coating structural materials2018

    • Author(s)
      Kohei Hashimoto, Hiroaki Takehara, and Takanori Ichiki
    • Organizer
      The 31th International Microprocesses and Nanotechnology Conference (MNC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High aspect ratio microneedles of bioabsorbable polymer fabricated by micromolding2018

    • Author(s)
      Yukihiro Kanda, Hiroaki Takehara, and Takanori Ichiki
    • Organizer
      Proceedings of micro-TAS 2018 Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血中滞在ナノ粒子の体内計測を目指した光学モデル検討2018

    • Author(s)
      竹原宏明, 一木隆範
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] モールディングにより成形した生分解性ポリマー微小構造体の材料強度評価2018

    • Author(s)
      神田循大, 竹原宏明, 一木隆範
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Light delivery inside the body with the combined use of optical semiconductors and hydrogel waveguides2017

    • Author(s)
      Hiroaki Takehara, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      9th International Conference of Molecular Electronics and Bioelectronics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Implantable bio-LSI chips toward optical diagnosis and treatment inside body2017

    • Author(s)
      Hiroaki Takehara, Takanori Akagi, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta, and Takanori Ichiki
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] インプラントLSIデバイスが実現する未来型医療に向けたIoT技術2017

    • Author(s)
      竹原宏明
    • Organizer
      電子情報通信学会ソサイエティ大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 半導体技術を応用した埋め込み型バイオデバイス~ラボオンブレイン・インプラント半導体センサ~2017

    • Author(s)
      竹原宏明
    • Organizer
      医工学ネットワークシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] n On-Chip Fluorescence Imaging System Using a Compact CMOS Image Sensor2016

    • Author(s)
      Hiroaki Takehara, Kazutaka Osawa, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta,
    • Organizer
      2016 International Conference on Solid State Devices and Materials (SSDM 2016)
    • Place of Presentation
      Tsukuba
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Implantable medical LSI-chips integrated with flexible and biocompatible hydrogel optical fibers2016

    • Author(s)
      Hiroaki Takehara, Yuji Katsuragi, Hajime Hayami, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      2016 International Conference on Flexible and Printed Electronics (ICFPE 2016)
    • Place of Presentation
      Yamagata University
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hydrogel-based optical devices for light delivery inside tissues2016

    • Author(s)
      Hiroaki Takehara
    • Organizer
      The 33rd International Conference of Photopolymer Science and Technology (ICPST-33)
    • Place of Presentation
      International Conference Hall Makuhari Messe, Chiba, Japan
    • Year and Date
      2016-06-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Implantable microdevices based on semiconductor technology for optical cell analysis in vivo2016

    • Author(s)
      Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
    • Organizer
      The 11th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2016)
    • Place of Presentation
      Hotel Matsushima Taikanso, Miyagi, Japan
    • Year and Date
      2016-04-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 埋植型デバイスへの導入に向けたハイドロゲルの光学特性評価2016

    • Author(s)
      桂木優治, 須永圭紀, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳
    • Organizer
      2016年第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] CMOSイメージセンサを用いた培養細胞のオンチップ蛍光計測システム2016

    • Author(s)
      大澤和嵩, 竹原宏明, 野田俊彦, 笹川清隆, 徳田崇, 太田淳
    • Organizer
      2016年第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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