Novel Therapeutic Strategy using Direct Reprogramming Methods for Stroke
| Project/Area Number |
15K21181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
General medical chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
Yamashita Toru 岡山大学, 医歯薬学総合研究科, 講師 (60644408)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脳梗塞 / 細胞移植 / iN細胞 / iPS細胞 / ダイレクトリプログラミング / iNS細胞 / 細胞移植療法 |
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| Outline of Final Research Achievements |
We investigated the therapeutic effect of iNSC transplantation, and also monitored engrafted iNSCs after transplantation of undifferentiated murine iNSCs in ischemic striatum/cortex of the mouse brain.
We found that iNSC transplantation successfully improved the survival rate of stroke model mice with significant functional recovery from the stroke. The fate of engrafted iNSCs was that the majority of iNSCs had differentiated into astroglial cells but not into neural cells in both the sham-operated brain and the poststroke brain without forming a tumor up to 8 months after tMCAO.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Novel Therapeutic Transplantation of Induced Neural Stem Cells for Stroke.2017
Author(s)
Yamashita T, Liu W, Matsumura Y, Miyagi R, Zhai Y, Kusaki M, Hishikawa N, Ohta Y, Kim SM, Kwak TH, Han DW, Abe K.
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Journal Title
Cell Transplant.
Volume: Mar 13;26(3)
Issue: 3
Pages: 461-467
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] High Incidence of Dementia Conversion than Stroke Recurrence in Poststroke Patients of Late Elder Society.2015
Author(s)
Nakano Y, Deguchi K, Yamashita T, Morihara R, Matsuzono K, Kawahara Y, Sato K, Kono S, Hishikawa N, Ohta Y, Higashi Y, Takao Y, Abe K.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 24
Issue: 7
Pages: 1621-8
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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