Feasibility of sequence memory based on theta traveling waves in the hippocampus
| Project/Area Number |
15K21193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
Soft computing
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Samura Toshikazu 山口大学, 大学院創成科学研究科, 准教授 (30566617)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 海馬 / CA3 / 時系列記憶 / シータリズム / 進行波 / ギャップ結合 / シータ進行波 / 神経活動伝播 / リカレントネットワーク |
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| Outline of Final Research Achievements |
In this study, we examined the formation of sequence memory that are implemented on the spatiotemporal representation of a sequence by theta traveling waves in the hippocampus. Our computer simulation demonstrated that the hippocampal CA3 has a neural substrate for the input-dependent effective organization of neuronal activities in addition to the organization of unidirectionally propagating neuronal activities that correspond to theta traveling waves. These results indicate that the hippocampal CA3 has a capability to represent sequential information spatially. It is suggested that the formation of sequence memory from the spatiotemporal representation of a sequence is feasible in the hippocampus.
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Report
(4 results)
Research Products
(8 results)
