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Development of the new quality assurance method for four-dimensional real-time tumor-tracking radiotherapy

Research Project

Project/Area Number 15K21194
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Radiation science
Research InstitutionYamaguchi University

Principal Investigator

SHIINOKI Takehiro  山口大学, 医学部附属病院, 助教 (30610456)

Research Collaborator YUASA Yuki  
FUJIMOTO Koya  
ONIZUKA Ryota  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords動体追跡放射線治療 / 品質管理法 / 呼吸性移動 / ログファイル解析 / 医用画像解析 / 被ばく線量計算 / 画像誘導放射線治療 / 品質管理 / 四次元放射線治療
Outline of Final Research Achievements

We developed the quality assurance method for respiratory-gated radiotherapy using new real-time tumor-tracking radiotherapy (RTRT) system. The RTRT system recognize the positions of the fiducial marker implanted near the liver and lung tumors in real time using two fluoroscopic images. We developed a software that can analyze the log file and made it possible to quantify respiratory motion of tumor. We also developed a software to verify accuracy during treatment using a log file and cine electronic portal image device and proved that treatment accuracy can be performed with an accuracy of ± 3 mm. In addition, the imaging dose calculation system during real-time tumor monitoring was constructed, making it possible to quantify and manage the imaging doses for each patient.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (46 results)

All 2018 2017 2016 2015

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 12 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Swyer-James Syndrome2018

    • Author(s)
      Hamada Kazuki、Oishi Keiji、Hirano Tsunahiko、Shiinoki Takehiro、Shibuya Keiko、Matsunaga Kazuto
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 197 Issue: 1 Pages: 130-131

    • DOI

      10.1164/rccm.201708-1691im

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of patient-specific imaging dose for real-time tumour monitoring in lung patients during respiratory-gated radiotherapy2018

    • Author(s)
      Shiinoki Takehiro、Onizuka Ryota、Kawahara Daisuke、Suzuki Tatsuhiko、Yuasa Yuki、Fujimoto Koya、Uehara Takuya、Hanazawa Hideki、Shibuya Keiko
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 6 Pages: 065016-065016

    • DOI

      10.1088/1361-6560/aab242

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of patient-specific bolus created using three-dimensional printing technique in photon radiotherapy2017

    • Author(s)
      Fujimoto Koya、Shiinoki Takehiro、Yuasa Yuki、Hanazawa Hideki、Shibuya Keiko
    • Journal Title

      Physica Medica

      Volume: 38 Pages: 1-9

    • DOI

      10.1016/j.ejmp.2017.04.023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 画像誘導・動体追跡放射線治療の臨床導入に向けた放射線治療技術の開発2017

    • Author(s)
      椎木健裕,澁谷景子
    • Journal Title

      BioClinica

      Volume: 7 Pages: 67-74

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of gantry speed on accuracy of extracted target motion trajectories and image quality in 4D-CBCT: phantom study2017

    • Author(s)
      Yuasa Yuki、Shiinoki Takehiro、Fujimoto Koya、Hanazawa Hideki、Uehara Takuya、Koike Masahiro、Shibuya Keiko
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 3 Issue: 6 Pages: 067001-067001

    • DOI

      10.1088/2057-1976/aa8ade

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a respiratory-induced lung tumor motion model using phase oscillator2017

    • Author(s)
      Naoto K, Fujii F, Shiinoki T, Shibuya K
    • Journal Title

      2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC)

      Volume: 1 Pages: 699-704

    • DOI

      10.1109/smc.2017.8122689

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of Well-Balanced kV X-Ray Imaging Conditions between Skin Dose and Image Noise for Dynamic Tumor Tracking Irradiation2017

    • Author(s)
      Nakai T, Sawada A, Tanabe H, Sueoka M, Taniuchi S, Takayama K, Shiinoki T, Ishihara Y, Kokubo M
    • Journal Title

      International Journal of Medical Physics, Clinical Engineering and Radiation Oncology

      Volume: 6 Issue: 04 Pages: 410-420

    • DOI

      10.4236/ijmpcero.2017.64037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Verification of respiratory-gated radiotherapy with new real-time tumour-tracking radiotherapy system using cine EPID images and a log file.2017

    • Author(s)
      Shiinoki T, Hanazawa H, Yuasa Y, Fujimoto K, Uehara T, Shibuya K.
    • Journal Title

      Phys Med Biol.

      Volume: 62 Issue: 4 Pages: 1585-1599

    • DOI

      10.1088/1361-6560/aa587d

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical assessment of coiled fiducial markers as internal surrogates for hepatocellular carcinomas during gated stereotactic body radiotherapy with a real-time tumor-tracking system2017

    • Author(s)
      Hanazawa H, Takahashi S, Shiinoki T, Park SC, Yuasa Y, Koike M, Kawamura S, Shibuya K.
    • Journal Title

      Radiother Oncol

      Volume: 123 Issue: 1 Pages: 43

    • DOI

      10.1016/j.radonc.2017.02.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a combined respiratory-gating system comprising the TrueBeam linear accelerator and a new real-time tumor-tracking radiotherapy system: a preliminary study2016

    • Author(s)
      Shiinoki T, Kawamura S, Uehara T, Yuasa Y, Fujimoto K, Koike M, Sera T, Emoto Y, Hanazawa H, Shibuya K.
    • Journal Title

      J Appl Clin Med Phys.

      Volume: 17 Issue: 4 Pages: 202

    • DOI

      10.1120/jacmp.v17i4.6114

    • URL

      https://pure.teikyo.jp/en/publications/95279bee-7fa5-4d18-81b5-f269ad94c89f

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 画像誘導・動体追跡放射線治療2016

    • Author(s)
      椎木健裕、澁谷景子
    • Journal Title

      カレントテラピー

      Volume: 34 Pages: 485-490

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dosimetric impact of dental metallic crown on intensity-modulated radiotherapy and volumetric-modulated arc therapy for head and neck cancer2016

    • Author(s)
      Takeshi Kamomae, Yoshiyuki Itoh, Kuniyasu Okudaira, Takayoshi Nakaya, Masashi Tomida, Yoshikazu Miyake, Hiroshi Oguchi, Takehiro Shiinoki, Mariko Kawamura, Noriyuki Yamamoto, Shinji Naganawa
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 17 Issue: 1 Pages: 234-245

    • DOI

      10.1120/jacmp.v17i1.5870

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of the incident directional dependence of radiochromic film by use of Monte Carlo simulation and measurement2016

    • Author(s)
      Yuasa Y, Kawamura S, Shiinoki T, Uehara T, Koike M, Kanzaki R, Hanazawa H, Takahashi S, Shibuya K
    • Journal Title

      Radiol Phys Technol

      Volume: 9 Issue: 2 Pages: 227

    • DOI

      10.1007/s12194-016-0353-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Estimation of Patient-specific Imaging Dose for Real-Time Tumor-Tracking in Lung During Respiratory-Gated Radiotherapy2017

    • Author(s)
      Shiinoki T, Kawahara D, Onizuka R, Suzuki T, Yuasa Y, Fujimoto K, Uehara T, Hanazawa H, Shibuya K
    • Organizer
      59th American Association of Physicists in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Gantry Speed on Accuracy of Extracted target motion trajectories and image quality in 4D-CBCT: phantom study2017

    • Author(s)
      Yuasa Y, Shiinoki T, Fujimoto K, Hanazawa H, Uehara T, Koike M, Shibuya K
    • Organizer
      59th American Association of Physicists in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Patient-Specific Quality Assurance of Respiratory-Gated Radiotherapy for Lung Using New Real-Time Tumor-Tracking Radiotherapy System2017

    • Author(s)
      Shiinoki T, Uehara T, Sera T, Yuasa Y, Fujimoto F, Koike M, Hanazawa H, Shibuya K.
    • Organizer
      59th American Association of Physicists in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reproducibility of CT Ventilation Imaging Based On Breath-Hold CT Toward Functional Image-Guided Adaptive Radiotherapy for Lung2017

    • Author(s)
      Onozato Y, Shiinoki T, Hanazawa H, Shibuya K.
    • Organizer
      59th American Association of Physicists in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Construction of a respiratory-induced lung tumor motion model using phase oscillator2017

    • Author(s)
      Kashibe N, Fujii F, Shiinoki T, Shibuya K.
    • Organizer
      2017 IEEE SMC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 4D-CBCTのガントリ回転速度に対する腫瘍位置精度と画質に関する検討2017

    • Author(s)
      湯浅勇紀、椎木健裕、藤本昂也、世良竜大、上原拓也、澁谷景子
    • Organizer
      第45回日本放射線技術学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超高線量率動体追跡放射線治療に向けたMV/kVの同時ばく射に関する追跡精度評価システムの開発2017

    • Author(s)
      上原拓也, 椎木健裕, 花澤豪樹, 小池正紘, 三品幸男, 加治木駿介, 田辺悦章, 澁谷景子
    • Organizer
      第45回日本放射線技術学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高線量率MV照射による散乱線が肝動体追跡放射線治療における透視追跡精度に及ぼす影響2017

    • Author(s)
      花澤豪樹,椎木健裕,上原拓也,高橋昌太郎,小池正紘,湯浅勇紀,朴成哲,三品幸男, 加治木駿介, 田辺悦章, 澁谷景子
    • Organizer
      第30回放射線腫瘍学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 最適化アルゴリズムの解像度がVMAT治療計画に及ぼす影響2017

    • Author(s)
      世良竜大、椎木健裕、田辺悦章、湯浅勇紀、上原拓也、澁谷景子
    • Organizer
      第30回放射線腫瘍学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線治療の呼吸性移動対策のための4次元コーンビームCTの臨床評価2016

    • Author(s)
      湯浅勇紀、椎木健裕、藤本昂也、世良竜大、上原拓也、澁谷景子
    • Organizer
      第12回中国四国放射線医療技術フォーラム
    • Place of Presentation
      島根県民会館(島根県松江市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Cine EPIDとログファイルを用いた画像誘導・動体追跡照射の照射精度検証法の開発2016

    • Author(s)
      椎木健裕、花澤豪樹、湯浅勇紀、藤本昂也、上原拓也、澁谷景子
    • Organizer
      第44回放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 3Dプリンタにより作成した患者個別ボーラスの有用性2016

    • Author(s)
      藤本昂也、椎木健裕、湯浅勇紀、澁谷景子
    • Organizer
      第44回放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 放射線治療の呼吸性移動対策のための4次元コーンビームCTの基礎的評価2016

    • Author(s)
      湯浅勇紀、椎木健裕、藤本昂也、世良竜大、上原拓也、澁谷景子
    • Organizer
      第44回放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 新型動体追跡装置を用いた肺腫瘍に対する画像誘導・動体追跡照射の患者個別QA2016

    • Author(s)
      上原拓也、椎木健裕、世良竜大、湯浅勇紀、小池正紘、澁谷景子
    • Organizer
      第44回放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 呼吸性移動対策における利益と課題2016

    • Author(s)
      椎木健裕
    • Organizer
      第44回放射線技術学会秋季学術大会
    • Place of Presentation
      ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Analysis of dosimetric parameters with or without flattening filter in gating and non-gating stereotactic body radiotherapy for lung tumors: planning study2016

    • Author(s)
      Hanazawa H, Shiinoki T, Takahashi S, Park S, Nabeya K, Fujimoto K, Yuasa Y, Koike M, Tanabe Y, Kawamura S, Shibuya K
    • Organizer
      2016 American Society for Radiation Oncology
    • Place of Presentation
      USA, Boston, MA
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線治療に向けた肺腫瘍の位置予測モデルの構築2016

    • Author(s)
      樫部直人, 藤井文武, 澁谷景子, 椎木健裕, 川村慎二, 田辺悦章
    • Organizer
      Dynamics and Design Conference 2016
    • Place of Presentation
      山口大学(山口県宇部市)
    • Year and Date
      2016-08-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Dual modality verification for respiratory gating using new real-time tumor-tracking radiotherapy system2016

    • Author(s)
      Shiinoki T, Kawamura S, Koike M, Yuasa Y, Uehara T, Fujimoto K, Hanazawa H, Shibuya K
    • Organizer
      58th American Association of Physicists in Medicine
    • Place of Presentation
      USA, Washington, DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feasibility study of markerless tracking using dual energy fluoroscopic images for real-time tumor-tracking radiotherapy system2016

    • Author(s)
      Shiinoki T, Sawada A, Uehara T, Yuasa Y, Koike M, Kawamura S, Shibuya K
    • Organizer
      58th American Association of Physicists in Medicine
    • Place of Presentation
      USA, Washington, DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effectiveness of a patient specific bolus moade by using three-dimensional printing technique in photon radiotherapy2016

    • Author(s)
      Fujimoto K, Shiinoki T, Yuasa Y, Hanazawa, Shibuya K
    • Organizer
      58th American Association of Physicists in Medicine
    • Place of Presentation
      USA, Washington, DC
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of dose calculation accuracy based on cone beam cumputed tomography images for adaptive radiation therapy2016

    • Author(s)
      Yuasa Y, Shiinoki T, Uehara T, Koike M, Sera T, Emoto Y, Kawamura S
    • Organizer
      72nd Japan Society of Radiological Technology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 画像誘導放射線治療2016

    • Author(s)
      椎木 健裕
    • Organizer
      日本放射線腫瘍学会 物理学セミナー
    • Place of Presentation
      広島高精度放射線治療センター(広島県広島市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Is radiotherapy for a patient under the mechanical ventilation always contraindicated?2015

    • Author(s)
      Hanazawa H,Takahashi S,Park S,Shiinoki T,Kawamura S,Shibuya K
    • Organizer
      28th Annual Meeting of JASTRO
    • Place of Presentation
      ベイシア文化ホール/前橋商工会議所会館(群馬県前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Pathological complete response was achieved after chemoradiotherapy for locally advanced pancreatic cancer;a case study2015

    • Author(s)
      Park S, Takahashi S, Hanazawa H, Shiinoki T, Shibuya K
    • Organizer
      28th Annual Meeting of JASTRO
    • Place of Presentation
      ベイシア文化ホール/前橋商工会議所会館(群馬県前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 放射線治療装置用動体追跡システムSyncTraXとTrueBeam-クリニカルコミッショニングについて-2015

    • Author(s)
      椎木 健裕
    • Organizer
      28th Annual Meeting of JASTRO
    • Place of Presentation
      ベイシア文化ホール/前橋商工会議所会館(群馬県前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 地域放射線治療支援のための品質管理ソフトウェアの開発 -フィルム解析編-2015

    • Author(s)
      椎木健裕、藤本和男、上原拓也、湯浅勇紀、田口耕太郎
    • Organizer
      CSFRT2015
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 新型動体追跡装置におけるColor.IIの性能評価2015

    • Author(s)
      世良竜大、上原拓也、椎木健裕、小池正紘、湯浅勇紀、川村慎二
    • Organizer
      CSFRT2015
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Motion management2015

    • Author(s)
      椎木 健裕
    • Organizer
      医学物理学会サマーセミナー
    • Place of Presentation
      グリンピア瀬戸内(広島県呉市)
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung using real-time tumor-tracking radiotherapy system.2015

    • Author(s)
      T Shiinoki, S Kawamura, H Hanazawa, S Park, T Uehara, Y Yuasa, M Koike, T Takahashi, K Shibuya
    • Organizer
      57th American Association of Physicists in Medicine
    • Place of Presentation
      USA, Anaheim, CA
    • Year and Date
      2015-07-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] SBRT for hepatocellular carcinoma using gated radiotherapy with RTRT system and coiled fiducial markers: a report on initial 14 experience.2015

    • Author(s)
      Hanazawa H, Takahashi S, Park S, Shiinoki T, Shibuya K
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of the tumor respiratory motion analysis tools using log files for four dimensional radiotherapy2015

    • Author(s)
      Shiinoki Takehiro, Uehara Takuya, Kawamura Shinji, Yuasa Yuki, Fujimoto Koya, Koike Masahiro, Shibuya Keiko
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of the tumor respiratory motion analysis tools using log files for dour dimensional radiotherapy2015

    • Author(s)
      Shiinoki Takehiro, Uehara Takuya, Kawamura Shinji, Yuasa Yuki, Fujimoto Koya, Koike Masahiro, Shibuya Keiko
    • Organizer
      71st Japan Society of Radiological Technology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Book] PartⅡ-17 Pancreatic Canser,Intensity-Modulated Radiation Therapy - Clinical Evidence and Techniques2015

    • Author(s)
      Shibuya K, Shiinoki T, Nakamura A
    • Total Pages
      473
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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