Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Outline of Final Research Achievements |
Some of polybrominated dibenzo-p-dioxin congeners (PBDDs) including di-/triBDDs are ubiquitously detected in marine sediments and organisms. To understand the response to the PBDD exposure, we conducted RNA-seq analysis of the transcriptome in mysids treated with vehicle or 1,3,7-TriBDD. For comparison, the transcriptomes in mysids treated with TCDD, Kanechlor-500 (KC-500), and bisphenol A were also analyzed. The gene expression patterns showed that the transcriptome response to 1,3,7-TriBDD was different from those to chlorinated analogues, TCDD and KC-500. Heat map and K-mean cluster analyses revealed that myosin-related genes were markedly down-regulated by 1,3,7-TriBDD exposure, implying that 1,3,7-TriBDD might influence the behavior of mysid. These results suggest that PBDDs may have a potential to elicit adverse effects in the mysid through a distinct mechanism from other chemicals.
|