Mechanism of tumor rebound after discontinuation of anti-VEGF treatment
Project/Area Number |
15K21205
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Laboratory animal science
Tumor biology
|
Research Institution | Iwate University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 血管新生 / 分子標的薬 / VEGF / 血管新生阻害薬 / 分子標的 / VEGF阻害剤 / in vivo イメージング / 腫瘍 |
Outline of Final Research Achievements |
Mouse mammary tumor cell line 4T1 cell were used. BALB/c mice were injected with 4T1 cells and divided into 4 groups (group A: base line control, group B: 7-days treatment with sunitinib (40 mg/kg, QD), group C: 7-days treatment with sunitinib plus 7-days withdraw, group D: 7-days treatment with vehicle plus 7-days withdraw). Mice were perfused at Day1 (group A), Day7 (group B), and Day14 (group C and D) and analysed by immunohistochemistry. In the group B, a significant decrease of blood vessel density was observed. In the group C, blood vessel density was comparable with group A, that means that decreased blood vessels rapidly recovered after sunitinib withdrawal. The tumor invasiveness to surrounding tissue was much greater in group C than in group B. However, incidence of distant metastasis was comparable between group B and C.
|
Report
(3 results)
Research Products
(5 results)
-
[Journal Article] Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown2017
Author(s)
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A
-
Journal Title
JCI Insight
Volume: 2
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-