Monitoring of the hemoglobin oxygen saturation via the ultra-high sensitive NMR signals
Project/Area Number |
15K21218
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
Radiation science
|
Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016-2017) The University of Tokyo (2015) |
Principal Investigator |
Takakusagi Yoichi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主任研究員(任常) (60439916)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 超偏極 / NMR / MRI / CEST / BOLD / ヘモグロビン / 酸素 / がん / 酸素飽和度 / 造影剤 / 赤血球 / 動的可視化 |
Outline of Final Research Achievements |
Nuclear magnetic resonance (imaging) (NMR/MRI) is a technique which uses a radio frequency pulse as a principle for the excitation/relaxation of nuclear spins, and widely used not only the determination of the molecular structure of compounds, but also the noninvasive imaging deep part of the body. However, "the low sensitivity" is a fundamental and the greatest drawback of this technique. To address these issues, new imaging methodologies, such as dynamic nuclear polarization (DNP) or chemical exchange saturation transfer (CEST), have recently been emerged. In the present study, generation and application of brand-new MR probes that allow in situ monitoring of the oxygen molecule release from hemoglobin with high sensitivity were conducted.
|
Report
(4 results)
Research Products
(25 results)
-
-
-
-
-
-
-
-
[Journal Article] 13C-MR spectroscopic imaging with hyperpolarized [1-13C]pyruvate detects early response to radiotherapy in SCC tumors and HT-29 tumors2015
Author(s)
Keita Saito, Shingo Matsumoto, Yoichi Takakusagi, Masayuki Matsuo, H. Douglas Morris, Martin J. Lizak, Jeeva P. Munasinghe, Nallathamby Devasahayam, Sankaran Subramanian, James B. Mitchell, Murali C. Krishna,
-
Journal Title
Clin Cancer Res
Volume: 21
Issue: 22
Pages: 5073-5081
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Presentation] Noninvasive assessment of drug actions in tumor microenvironment by the EPR oxygen imaging2015
Author(s)
Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Kaori Takakusagi, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Robert J. Gillies, Charles P. Hart, James B. Mitchell, Murali C. Krishna
Organizer
第 54 回電子スピンサイエンス学会年会 (SEST2015)
Place of Presentation
朱鷺メッセ (新潟)
Year and Date
2015-11-02
Related Report
-
[Presentation] EPR based imaging biomarkers to guide treatment in tumor bearing mice2015
Author(s)
Shingo Matsumoto, Keita Saito, Shun Kishimoto, Yoichi Takakusagi, Hironobu Yasui, Masayuki Matsuo, Murali C. Krishna
Organizer
The 54th Annual Meeting of the Society of Electron Spin Science and Technology (SEST2015), International EPR Society Silver Medal Award Lecture
Place of Presentation
朱鷺メッセ (新潟)
Year and Date
2015-11-02
Related Report
Int'l Joint Research / Invited
-
-
-
[Presentation] Increase in tumor oxygenataion and radiosensitivity caused by SQAP (CG-0321): the mechanism of actions revealed by in vivo imaging studies2015
Author(s)
Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Kaori Takakusagi, Shun Kishimoto, Masahiro Ishima, Hiroshi Murata, Keisuke Ohta, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, James B. Mitchell, Murali C. Krishna
Organizer
International Conference of Radiation Research (ICRR2015)
Place of Presentation
京都国際会館
Year and Date
2015-05-25
Related Report
Int'l Joint Research
-
[Presentation] 13C-MRI with hyperpolarized [1-13C]pyruvate detects metabolic changes in SCC tumors and HT-29 tumors by radiotherapy2015
Author(s)
Keita Saito, Shingo Matsumoto, Yoichi Takakusagi, Masayuki Matsuo, H. Douglas Morris, Martin J. Lizak, Jeeva P. Munasinghe, Nallathamby Devasahayam, Sankaran Subramanian, James B. Mitchell, Murali C. Krishna
Organizer
International Conference of Radiation Research (ICRR2015)
Place of Presentation
京都国際会館
Year and Date
2015-05-25
Related Report
Int'l Joint Research
-
-