| Project/Area Number |
15K21236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Laboratory medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Research Collaborator |
ISOMOTO Hajime 鳥取大学, 医学部附属病院・消化器内科, 教授 (90322304)
OGIHARA Kumi 長崎大学, 病院(医学系), 医員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 光線力学的診断 / 消化管癌 / 光線力学診断 / 光線力学療法 |
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| Outline of Final Research Achievements |
Photodynamic diagnosis (PDD) is an imaging method by administering a photosensitizer that collects in cancer cells, irradiating the lesion with laser light (excitation light), and fluorescing the cancer. It is advantageous as a simple and less invasive diagnostic method for early cancer. It also leads to photodynamic therapy (PDT) using this principle. This study examined the usefulness of PDD in gastrointestinal cancer. It was confirmed that it is useful for lesion identification in gastric cancer and Barrett's esophageal cancer. However, in gastric cancer with low degree of differentiation, the detection rate was low, and it was revealed that the metabolism of photosensitizer in cancer cells is affecting the cause.
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