Predictive tool for endocrine response of breast cancer
Project/Area Number |
15K21237
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
General surgery
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Research Institution | Kumamoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 乳癌 / ホルモン療法 / 効果予測 / 乳がん / 効果予測因子 |
Outline of Final Research Achievements |
①DNA copy number abberation algorithm of pre-treatment tumor DNA showed little relationship to Ki67 decrease between pre- and post treatment. ②Whole blood RNA were analyzed by 90 cases. Test set (N=10) revealed microRNAs, which were correlated with PEPI score, such as miR503-5p, miR127-3p, miR135b-5p, miR126-3p, let7e-3, and miR647.These microRNAs had been reported as factor of cancer initiation and progression.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.2016
Author(s)
2.Tomiguchi M, Yamamoto Y, Yamamoto-Ibusuki M, Goto-Yamaguchi L, Fujiki Y, Fujiwara S, Sueta A, Hayashi M, Takeshita T, Inao T, Iwase H.
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Journal Title
Cancer Sci.
Volume: 107(4)
Issue: 4
Pages: 491-8
DOI
Related Report
Peer Reviewed
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[Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016
Author(s)
Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
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Journal Title
Cancer Sci
Volume: in press
Issue: 4
Pages: 469-477
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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