Cardio-splenic interaction in atrial fibrillation with hypertension and diabetes
Project/Area Number |
15K21245
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
General physiology
|
Research Institution | Oita University |
Principal Investigator |
Kondo Hidekazu 大分大学, 医学部, 病院特任助教 (90724170)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 心房細動 / 圧負荷 / 脾臓 / インターロイキン10 / 線維化 / 脾臓由来IL-10 / 圧負荷モデル / 繊維化抑制 / IL-10 |
Outline of Final Research Achievements |
The role of the spleen in inflammatory atrial fibrosis induced by pressure overload is unknown. We investigated whether splenectomy (SPX) attenuates or exacerbates pressure overload-induced atrial inflammatory fibrosis and vulnerability to atrial fibrillation (AF) in rats. Male Sprague Dawley rats (6 weeks old) were divided into Sham+Sham, Sham+SPX, abdominal aortic constriction (AAC)+Sham, and AAC+SPX groups, and were evaluated for inflammation, fibrosis, and AF on days 2, 4, 14, and 28. (P<0.05). As a results, SPX exacerbates AAC-induced inflammatory atrial fibrosis and increases vulnerability to AF after 4 weeks, likely due to the depletion of spleen-derived IL-10.
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Report
(3 results)
Research Products
(2 results)