Elucidation of the blood pressure adjustment mechanism using 3MST knockout mouse
| Project/Area Number |
15K21252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
Anesthesiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Totsuka Yuichi 琉球大学, 医学部附属病院, 医員 (30747704)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 3MST / 高血圧 / 硫化水素 |
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| Outline of Final Research Achievements |
It came to be known that hydrogen sulfide was gas with a wide variety of bioactivity including vasodilator action, cytoprotective property, inhibitory effect of ischemic reperfusion injury, anti-inflammatory action. We paid attention to one of the hydrogen sulfide synthase 3-Mercaptopyruvate(3MST) using 3MST-KO and WT mouse. We found that 3MST-KO mouse was hypertension. Cardiac output was comparable between both groups, whereas peripheral vascular resistance was increased in a group of 3MST-KO. There were plasma PGI2 decrease and urinary 8-isoprostane increase in 3MST-KO, and it was suggested that an oxidative stress increase was associated with a part for a mechanism of the vascular resistance increase.
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Report
(3 results)
Research Products
(2 results)
