Exploring the origin of difference in salt sensitivity of blood pressure between rats and humans from characteristic disparity in amino acid metabolism

Research Project

Project/Area Number	15K21263
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine Environmental physiology(including physical medicine and nutritional physiology)
Research Institution	Tokyo Women's Medical University
Principal Investigator	Yatabe Midori 東京女子医科大学, 医学部, 講師 (30510325)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	食塩感受性 / 高血圧 / 種差 / リジン / アミノ酸 / 腸内細菌 / 食塩摂取 / 血圧 / 利尿 / 食塩 / ラット
Outline of Final Research Achievements	Salt sensitivity of blood pressure is weaker in rodents compared to humans. We showed from plasma and urine amino acid analysis that plasma lysine dynamics is different between rats and humans. Because plasma lysine concentration is lower in hypertensive model rats compared to control rats and lysine supplementation increased urinary volume, lysine may be involved in blood pressure control and salt sensitivity. Fecal amino acid analysis suggested decreased intestinal production of lysine by gut flora in hypertensive model rats have compared to control rats and that rats may have increased intestinal absorption of lysine during salt load compared to humans.