The impact of gene-environmental interaction on head and neck cancer survival

• Project/Area Number: 15K21283
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology; Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: KAWAKITA Daisuke 名古屋市立大学, 大学院医学研究科, 研究員 (70584506)
• Research Collaborator: MATSUO Keitaro 愛知県がんセンター研究所, 遺伝子医療研部 ; HASEGAWA Yasuhisa 愛知県がんセンター, 中央病院頭頸部外科
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 頭頸部がん / 遺伝環境交互作用 / 飲酒 / アルデヒド脱水素酵素 / 予後 / 頭頸部癌 / アセトアルデヒド脱水素酵素 / 微小栄養素 / 口腔衛生 / 予後因子 / 遺伝子多型

Outline of Final Research Achievements

We performed a retrospective cohort study of 267 head and neck squamous cell carcinoma (HNSCC) patients at Aichi Cancer Center. The prognostic value of pre-treatment drinking status and aldehyde dehydrogenase 2 (ALDH2) polymorphism was investigated using multivariate proportional hazard models.
Pretreatment drinking status and ALDH2 genotype was not significantly associated with survival in HNSCC patients. After stratification by ALDH2 genotype, we observed a significant positive dose-response relationship between drinking status and disease-free survival in HNSCC patients with ALDH2 Glu/Glu (Ptrend = 0.029).
To confirm this association, we should consider a drinking behavior change after treatment.

Research Products

• [Journal Article] Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan. (2017)
  • Author(s): Kawakita D, Tada Y, Imanishi Y, Beppu S, Tsukahara K, Kano S, Ozawa H, Okami K, Sato Y, Shimizu A, Sato Y, Fushimi C, Takase S, Okada T, Sato H, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Shimura T, Hanazawa T, Murakami S, Nagao T.
  • Journal Title: Oncotarget Volume: 8(1) Issue: 1 Pages: 1083-1091
  • DOI: 10.18632/oncotarget.13565
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Heterogeneous impact of alcohol consumption according to treatment method on survival in head and neck cancer: A prospective study. (2017)
  • Author(s): Sawabe M, Ito H, Oze I, Hosono S, Kawakita D, Tanaka H, Hasegawa Y, Murakami S, Matsuo K.
  • Journal Title: Cancer Sci Volume: 108 Issue: 1 Pages: 91-100
  • DOI: 10.1111/cas.13115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas. (2017)
  • Author(s): Carioli G, Negri E, Kawakita D, Garavello W, La Vecchia C, Malvezzi M.
  • Journal Title: International of Cancer Volume: 140(10) Issue: 10 Pages: 2256-2264
  • DOI: 10.1002/ijc.30660
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Striated duct adenoma presenting with intra-tumoral hematoma and papillary thyroid carcinoma-like histology. (2017)
  • Author(s): Ito Y, Fujii K, Murase T, Saida K, Okumura Y, Takino H, Masaki A, Beppu S, Kawakita D, Ijichi K, Inagaki H.
  • Journal Title: Pathology International Volume: 印刷中 Issue: 6 Pages: 316-321
  • DOI: 10.1111/pin.12534
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of drinking status and aldehyde dehydrogenase 2 polymorphism in patients with head and neck squamous cell carcinoma. (2016)
  • Author(s): Kawakita D, Oze I, Hosono S, Ito H, Watanabe M, Yatabe Y, Hasegawa Y, Murakami S, Tanaka H, Matsuo K
  • Journal Title: Journal of Epidemiology Volume: In press
  • NAID: 130005154812
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functional Nerve Preservation in Extracranial Head and Neck Schwannoma Surgery. (2016)
  • Author(s): Ijichi K, Kawakita D, Maseki S, Beppu S, Takano G, Murakami S.
  • Journal Title: JAMA Otolaryngol Head Neck Surg Volume: In press Issue: 5 Pages: 479-479
  • DOI: 10.1001/jamaoto.2016.0113
  • Peer Reviewed
• [Journal Article] Clinical outcomes and prognostic factors for salivary duct carcinoma: A multi-institutional analysis of 141 patients. (2016)
  • Author(s): Otsuka K, Imanishi Y, Tada Y, Kawakita D, Hanazawa T, Chazono H, Kano S, Shimizu A, Tsukahara K, Okami K, Sakai A, Sato Y, Ueki Y, Sato Y, Ozawa H, Ogawa K, Nagao T.
  • Journal Title: Annals of Surgical Oncology Volume: In press
  • Peer Reviewed
• [Journal Article] Pathological response of salivary duct carcinoma to trastuzumab and docetaxel therapy (2016)
  • Author(s): Yushi Ueki, Yuichiro Tada, Takafumi Togashi, Daisuke Kawakita, Toshitaka Nagao, Yuichiro Sato
  • Journal Title: International Cancer Conference Journal Volume: In press
  • Peer Reviewed
• [Journal Article] Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion. (2015)
  • Author(s): Ito Y, Ishibashi K, Masaki A, Fujii K, Fujiyoshi Y, Hattori H, Kawakita D, Matsumoto M, Miyabe S, Shimozato K, Nagao T, Inagaki H.
  • Journal Title: The American journal of surgical pathology Volume: 39 (5) Issue: 5 Pages: 602-610
  • DOI: 10.1097/pas.0000000000000392
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Androgen receptor-positive mucoepidermoid carcinoma: case report and literature review. (2015)
  • Author(s): Ishibashi K, Ito Y, Fujii K, Masaki A, Beppu S, Kawakita D, Ijichi K, Shimozato K, Inagaki H.
  • Journal Title: International journal of surgical pathology Volume: 23 (3) Issue: 3 Pages: 243-247
  • DOI: 10.1177/1066896914565024
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Late effects among head and neck cancer survivors in Utah cancer survivorship study. (2017)
  • Author(s): Daisuke Kawakita, Sarah Abdelaziz, Yuji Chen, Kerry G. Rowe, Yuan Wan, Vikrant Deshmukh, Michael Newman, Alison M Fraser, Ken R Smith, Marcus Monroe, Mia Hashibe.
  • Organizer: 2017 ASCO Cancer Survivorship Symposium
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2017-01-27
  • Int'l Joint Research
• [Presentation] 唾液腺導管癌ではFOXA1の発現が予後予測因子となる (2016)
  • Author(s): 平井秀明、多田雄一郎、川北大介、志村智隆、塚原清彰、加納里志、小澤宏之、大上研二、佐藤雄一郎、清水顕、今西順久、長尾俊孝
  • Organizer: 第61回日本唾液腺学会学術集会
  • Place of Presentation: 文京学院大学本郷キャンパス (東京都文京区)
  • Year and Date: 2016-12-03
• [Presentation] 唾液腺導管癌における免疫組織学的発現解析-多施設共同による152症例の検討- (2016)
  • Author(s): 加納里志、高瀬聡一郎、多田雄一郎、川北大介、塚原清彰、清水顕、今西順久、小澤宏之、大上研二、佐藤雄一郎、佐藤由紀子、志村智隆、花澤豊行、長村義之、長尾俊孝
  • Organizer: 第54回日本癌治療学会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-10-20
• [Presentation] 総頸動脈損傷に対してカバードステントで救命を得た喉頭癌局所再発例 (2016)
  • Author(s): 三好晋平、川北大介、高橋真理子、村上信五、小栗恵介
  • Organizer: 第78回耳鼻咽喉科臨床学会総会・学術講演会
  • Place of Presentation: 城山観光ホテル (鹿児島県鹿児島市)
  • Year and Date: 2016-06-23
• [Presentation] Functional nerve preservation in parapharyngeal tumor surgery. (2016)
  • Author(s): Ijichi K, Kawakita D, Beppu S, Sawabe M, Murashima A, Murakami S.
  • Organizer: 7th International Congress of the World Federation of Skull Base Societies
  • Place of Presentation: 大阪国際会議場 (大阪府大阪市)
  • Year and Date: 2016-06-14
  • Int'l Joint Research
• [Presentation] 耳下腺がん側頭骨進展症例に対する手術戦略-側頭骨、顔面神経の切除方針 (2016)
  • Author(s): 伊地知圭、川北大介、別府慎太郎、澤部倫、小栗恵介、村嶋明大、村上信五
  • Organizer: 第117回日本耳鼻咽喉科学会通常総会
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市)
  • Year and Date: 2016-05-18
• [Presentation] 根治切除不能鼻腔粘膜悪性黒色腫に対する抗PD-1抗体療法の初期治療経験 (2016)
  • Author(s): 川北大介、別府慎太郎、蒲谷嘉代子、小栗恵介、三好晋平、澤部倫、伊地知圭、村上信五
  • Organizer: 第26回日本頭頸部外科学会
  • Place of Presentation: 名古屋国際会議場(愛知県、名古屋市)
  • Year and Date: 2016-01-29
• [Presentation] 唾液腺導管癌の臨床成績と予後因子 -多施設共同による141例の検討 (2015)
  • Author(s): 大塚邦憲、今西順久、多田雄一郎、川北大介、花澤豊行、茶薗英明、加納里志、清水顕、塚原清彰、大上研二、酒井昭博、佐藤雄一郎、植木雄志、佐藤由紀子、小澤宏之、小川 郁、長尾俊孝、
  • Organizer: 第60回日本唾液腺学会
  • Place of Presentation: 文京学院大学(東京都、文京区)
  • Year and Date: 2015-12-05
• [Presentation] 唾液腺導管癌における標的遺伝子変異と免疫組織化学的発現の検討 (2015)
  • Author(s): 志村智隆、多田雄一郎、川北大介、塚原清彰、加納里志、清水顕、今西順久、小澤宏之、大上研二、佐藤雄一郎、長尾俊孝、
  • Organizer: 第60回日本唾液腺学会
  • Place of Presentation: 文京学院大学(東京都、文京区)
  • Year and Date: 2015-12-05
• [Presentation] 唾液腺腫瘍手術における術中迅速免疫染色(Ki-67 index)の意義 (2015)
  • Author(s): 別府慎太郎、川北大介、伊地知圭 、小栗恵介、村上信五、伊藤洋平、稲垣 宏
  • Organizer: 第60回日本唾液腺学会
  • Place of Presentation: 文京学院大学(東京都、文京区)
  • Year and Date: 2015-12-05
• [Presentation] 喉頭癌咽頭再発に対して導入化学療法とセツキシマブ併用IMRT療法が著効した1例 (2015)
  • Author(s): 川北 大介、別府 慎太郎、濱島 有喜、村上 信五
  • Organizer: 第28回日本口腔咽頭科学会
  • Place of Presentation: ホテル阪神(大阪府、大阪市)
  • Year and Date: 2015-09-10
• [Presentation] 機能温存を考慮したTPF療法+セツキシマブ併用IMRT療法の治療成績 (2015)
  • Author(s): 川北大介、高野学、別府慎太郎、伊地知圭、柳剛、村上信五
  • Organizer: 第39回日本頭頸部癌学会、第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場(兵庫県、神戸市)
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] Prognostic Significance of Immunohistochemical Biomarkers in Salivary Duct Carcinomas (2015)
  • Author(s): Soichiro Takase, Akira Shimizu , Yuichiro Tada, Daisuke Kawakita, Satoshi Kano, Kiyoaki Tsukahara, Toshitaka Nagao
  • Organizer: 第39回日本頭頸部癌学会、第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場(兵庫県、神戸市)
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] 重症度に応じたBell麻痺の実践的治療 (2015)
  • Author(s): 川北大介、勝見さち代、江崎伸一、村上信五
  • Organizer: 第116回日本耳鼻咽喉科学会
  • Place of Presentation: 東京国際フォーラム(東京都、千代田区)
  • Year and Date: 2015-05-22