Development of novel boron-pharmaceuticals for BNCT using reduced dodecaborate
| Project/Area Number |
15K21291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
Bio-related chemistry
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ホウ素－中性子捕捉療法 / ドデカボレート / ホウ素薬剤 / ドデカボレート含有アミノ酸 / ドデカボレート含有ペプチド / BNCT / アルキルスルフィニウムドデカボレート / ホウ素アミノ酸 / ホウ素クラスター |
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) for cancer is based on the nuclear reaction of 10B with thermal/epithermal neutrons to yield high linear energy transfer alpha particles (4He) and recoiling 7Li nuclei in tumor cells. However, only two compounds are used for the BNCT, novel efficient boron-pharmaceuticals are highly demanded.
In the course of our developing studies on new boron carrier for BNCT, we investigate the useful boron source for the development of boron-pharmaceuticals for BNCT. As a result, we developed the medium-chain alkyl sulfoniododecaborate (MADB) as ideal boron source for the BNCT agent, because MADB containing compounds showed high cell membrane permeability, low cytotoxicity and high water-solubility, and these compounds could deliver large amount of boron to several kinds of tumor cells.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma2017
Author(s)
Futamura G, Kawabata S, Nonoguchi N, Hiramatsu R, Toho T, Tanaka H, Masunaga SI, Hattori Y, Kirihata M, Ono K, Kuroiwa T, Miyatake SI
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Journal Title
Radiat Oncol.
Volume: 12
Issue: 1
Pages: 26-26
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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