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Development of novel boron-pharmaceuticals for BNCT using reduced dodecaborate

Research Project

Project/Area Number 15K21291
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Bio-related chemistry
Research InstitutionOsaka Prefecture University

Principal Investigator

Hattori Yoshihide  大阪府立大学, 研究推進機構, 講師 (50514460)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsホウ素-中性子捕捉療法 / ドデカボレート / ホウ素薬剤 / ドデカボレート含有アミノ酸 / ドデカボレート含有ペプチド / BNCT / アルキルスルフィニウムドデカボレート / ホウ素アミノ酸 / ホウ素クラスター
Outline of Final Research Achievements

Boron neutron capture therapy (BNCT) for cancer is based on the nuclear reaction of 10B with thermal/epithermal neutrons to yield high linear energy transfer alpha particles (4He) and recoiling 7Li nuclei in tumor cells. However, only two compounds are used for the BNCT, novel efficient boron-pharmaceuticals are highly demanded.
In the course of our developing studies on new boron carrier for BNCT, we investigate the useful boron source for the development of boron-pharmaceuticals for BNCT. As a result, we developed the medium-chain alkyl sulfoniododecaborate (MADB) as ideal boron source for the BNCT agent, because MADB containing compounds showed high cell membrane permeability, low cytotoxicity and high water-solubility, and these compounds could deliver large amount of boron to several kinds of tumor cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Invited: 2 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma2017

    • Author(s)
      Futamura G, Kawabata S, Nonoguchi N, Hiramatsu R, Toho T, Tanaka H, Masunaga SI, Hattori Y, Kirihata M, Ono K, Kuroiwa T, Miyatake SI
    • Journal Title

      Radiat Oncol.

      Volume: 12 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s13014-017-0765-4

    • NAID

      120005997769

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of BoronicAcid-Containing Compounds2017

    • Author(s)
      Yoshihide Hattori, Takuya Ogaki, Miki Ishimura, Yoichiro Ohta and Mitsunori Kirihata
    • Journal Title

      Sensors

      Volume: 17 Issue: 10 Pages: 2036-2036

    • DOI

      10.3390/s17102436

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of Boronic Acid Containing Pharmaceuticals in Live Tumor Cells Using a Fluorescent Boronic Acid Sensor2016

    • Author(s)
      Y. Hattori, M. Ishimura, Y. Ohta, H. Takenaka, M. Kirihata
    • Journal Title

      ACS Sensors

      Volume: 1 Issue: 12 Pages: 1394-1397

    • DOI

      10.1021/acssensors.6b00522

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] アルキルスルホニオドデカボレート含有アミノ酸のBNCT用ホウ素キャリアーとしての評価2018

    • Author(s)
      服部能英
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ドデカボレート含有型BPAのホウ素キャリアーとしての評価2017

    • Author(s)
      服部能英
    • Organizer
      第14回日本中性子捕捉療法学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis and Biological Evaluation of Medium-Chain Alkyl Sulfoniododecaborate Containing p-Boronophenylalanine2017

    • Author(s)
      服部能英
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Detection of Boron Pharmaceuticals in Biological Environment2017

    • Author(s)
      服部能英
    • Organizer
      2017ホウ素栄養研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] DEVELOPMENT OF REDUCED THIODODECABORATE CONTAINING AMINO ACIDS AND PEPTIDES FOR BORON NEUTRON CAPTURE THERAPY2016

    • Author(s)
      服部能英、石村美紀、大田洋一郎、竹中宏志、上原幸樹、浅野智之、切畑光統
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] ドデカボレート含有アミノ酸類のホウ素キャリアーとしての評価2016

    • Author(s)
      服部 能英
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2016-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] ドデカボレートをホウ素源とする有機低分子型ホウ素キャリアーの開発2016

    • Author(s)
      服部能英、石村美紀、大田洋一郎、竹中宏志、上原幸樹、浅野智之、切畑光統
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 分子プローブを用いたホウ素薬剤の分布解析2016

    • Author(s)
      服部能英
    • Organizer
      第10回光生体超分子化学セミナー
    • Place of Presentation
      近畿大学
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 医療・診断をささえるペプチド科学 ―再生医療・DDS・診断への応用―2017

    • Author(s)
      監修:平野義明
    • Total Pages
      315
    • Publisher
      シームシー出版
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] ホウ素含有化合物2016

    • Inventor(s)
      服部能英、上原幸樹、切畑光統
    • Industrial Property Rights Holder
      服部能英、上原幸樹、切畑光統
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-148978
    • Filing Date
      2016-07-28
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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