| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Mitochondrial respiratory supercomplex consists of respiratory complexes with a constant rate. Implication of the respiratory supercomplex formation for reactivity has been considered through investigation of the heme electronic states of the respiratory terminal oxidase (CcO) by vibrational spectroscopy. Resonance Raman spectra of supercomplex, CcO monomer and the mixture of the supercomplex components have been compared to see if there are any difference in their electronic states. In those of reduced form and fully reduced CO-bound form in supercomplex, vibrational modes of Fe-His and Fe-CO were observed. It has been suggested that this tiny structural alteration observed in the supercomplex formation is different from the one accompanying elevation of reactivity through binding of regulatory factor to CcO.
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