Bystander effect induction mechanisms for radiotherapy optimizing biological effect
| Project/Area Number |
15K21313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
Radiation science
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| Research Institution | Hokkaido University of Science |
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Principal Investigator |
Sasaki Kohei 北海道科学大学, 保健医療学部, 准教授 (20736376)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイスタンダー効果 / モンテカルロ法 / 放射線影響 / コンピュータシミュレーション / DNA二本鎖切断 / 非標的効果 / シグナル伝達 / 活性酸素種 / カルシウムイオン / 数理モデル / モンテカルロシミュレーション |
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| Outline of Final Research Achievements |
This research aims to develop a method to estimate radiation effects using computer simulation. By conducting computer simulation using the phenomenon as a mathematical model, it becomes possible to cross-analyze knowledge obtained by cell biology and molecular biology.
New findings obtained in this research can be applied to analysis of effects on living cells due to radiation exposure and prediction of radiotherapy effect.
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Report
(4 results)
Research Products
(14 results)
