Mechanism of body fluid regulation by sodium-glucose cotransporter
| Project/Area Number |
15K21321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
Pharmacology in pharmacy
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Research Collaborator |
Vallon Volker カルフォルニア大学, サンディエゴ校・医学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | SGLT2阻害 / 体液量 / 利尿薬 / ホメオスタシス / Na利尿 / 生体電気インピーダンス / 浸透圧利尿 / SGLT / SGLT2阻害薬 / 体液貯留 / 生体恒常性 / 体水分量 / SGLT2 / Na輸送 / 生体電気インピーダンス法 / 糖尿病 |
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| Outline of Final Research Achievements |
We revealed that SGLT2 inhibitor has a potent Na diuretic action, while it plays an important role in maintenance of homeostasis of body fluid volume.
We clarified that 1) SGLT2 inhibition induces a sustained diuretic and natriuretic tone 2) homeostatic mechanisms are activated to stabilize body fluid volume, including compensatory increases in fluid and food intake in euvolemic non-diabeitc rats 3) SGLT2 inhibitor decreases body fluid volume with an increase in urine volume in hypertensive rats with fluid retention. In patients with diabetic kidney disease with fluid retention, SGLT2 inhibitor predominantly decreases extracellular fluid with a transient urinary Na excretion.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Sodium-Glucose cotransporter 2 Inhibition with Dapagliflozin Ameriorates Extracellular Volume Expansion in Diabetic Kidney Disease Patients2017
Author(s)
Masuda T, Ohara K, Murakami T, Imai T, Nakagawa S, Okada M, Miki A, Myoga A, Onishi A, Sekiguchi C, Miyazawa Y, Akimoto T, Saito O, Muto S, Nagata D
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Journal Title
POJ Diabetes and Obesity Management
Volume: 1
Pages: 1-8
Related Report
Peer Reviewed / Open Access
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[Presentation] Comparative Effect of SGLT2 Inhibitor Dapagliflozin and Loop Diuretic Furosemide on Fluid Distribution2018
Author(s)
Masuda T, Ken Ohara1, Takuya Murakami1, Toshimi Imai1, Saki Nakagawa1, Mari Okada1, Hiromichi Yoshizawa1, Atsushi Miki1, Akihiro Myoga1, Izumi Nagayama1, Taro Sugase1, Akira Onishi1, Chuji Sekiguchi2, Yasuharu Miyazawa2, Tetsu Akimoto1, Osamu Saito1, Shigeaki Muto1, Daisuke Nagata1
Organizer
ISN Frontiers 2018
Related Report
Int'l Joint Research
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[Presentation] Effect of Sodium-Glucose Cotransporter 2 Inhibitor on Fluid Distribution: Comprasion with Furosemide and Tolvaptan2017
Author(s)
Ohara K, Masuda T, Murakami T, Imai T, Nakagawa S, Okada M, Yoshizawa H, Miki A, Oka K, Asakura M, Sugase T, Onishi A, Akimoto T, Saito O, Muto S, Nagata D
Organizer
ASN Kidney Week 2017
Related Report
Int'l Joint Research
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