| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
As a low invasive treatment for the malignant tumors, boron neutron capture therapy is featured. This study focused on liposome and developed the novel boron cluster-modified PEG lipid derivative (PBL) that is able to deliver the 10B at high concentration in the tumor.
PBL could be modified to lipid film efficiently, and the liposome that prepared with it was low toxicity in vitro. And, the liposome succeeded in 20 ppm of boron concentration and above 5 of T/B ratio in 24 hours after administration to cancer-bearing mice. As a result, when irradiated neutron beam to it, the liposome showed a significant antitumor effect in comparison with each control group.
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