Investigation of the link between hepatitis C and porphyria cutanea tarda
| Project/Area Number |
15K21346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
Pharmacology in pharmacy
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| Research Institution | Teikyo Heisei University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | C型肝炎 / 晩発性皮膚ポルフィリン症 / ヘム生合成 / ポルフィリン / Ethanol / ヘム / ミトコンドリア / トランスポーター / ALAS1 / ポルフィリン症 |
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| Outline of Final Research Achievements |
Earlier reports have shown a high prevalence of hepatitis C virus (HCV) infection in patients with PCT. While these observations implicate HCV infection as a risk factor for PCT pathogenesis, the mechanism of interaction between the virus and porphyrin metabolism is unknown. Here, we showed that HCV core protein triggers abnormal porphyrin metabolism, expressed by excess coproporphyrin excretion and higher porphyrins synthesis rate, via the change in the expression of enzymes and transporters involved in heme synthesis pathway. In addition, we confirmed that HCV core protein strengthen the ethanol-induced increase in ALAS1 protein expression that is a rate-limiting enzyme in heme synthesis.
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Report
(4 results)
Research Products
(4 results)
