| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
D-Serine is an endogenous co-agonist for NMDA receptors and regulates neurotransmission and synaptic plasticity in the central nervous system. We have shown that D-serine is present in high concentration in dauer larva of nematode Caenorhabditis elegans, a multicellular model animal, and that D-serine is involved in several aspects of dauer development. We also found that one of mammalian serine racemase homologous genes is L-serine dehydratase and is involved indirectly in D-serine synthesis.
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