Studies on novel physiological functions of D-serine in nematode C. elegans
Project/Area Number |
15K21361
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
Insect science
|
Research Institution | Kitasato University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | D-セリン / 線虫 / 耐性幼虫 / L-セリンデヒドラターゼ / セリンラセマーゼ |
Outline of Final Research Achievements |
D-Serine is an endogenous co-agonist for NMDA receptors and regulates neurotransmission and synaptic plasticity in the central nervous system. We have shown that D-serine is present in high concentration in dauer larva of nematode Caenorhabditis elegans, a multicellular model animal, and that D-serine is involved in several aspects of dauer development. We also found that one of mammalian serine racemase homologous genes is L-serine dehydratase and is involved indirectly in D-serine synthesis.
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Report
(3 results)
Research Products
(5 results)