| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
This study revealed the association between the presence of anti-donor HLA antibody and the degree of fibrosis in transplanted liver grafts. The detailed analysis of the trend of donor specific antibody was performed in patients who developed acute antibody mediated rejection, and provided the clinical strategies to prevent and control humoral immunity in sensitized recipients or recipients with refractory rejection. We also reported that desensitization might prevent recurrent primary sclerosing cholangitis after liver transplantation based on the national data.
In animal model, we analyzed the molecular mechanism in the binding of target endothelial cells and anti-MHC antibody, utilizing liver endothelial cells and pulmonary endothelial cells. In the microarray analysis, Proteocadherin 10 and Trpm2 are upregulated in liver endothelial cells to higher degree than pulmonary endothelial cells, which potentially indicate the protective mechanism of liver grafts.
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