Mechanism of resistance to antibody mediated rejection in liver transplantation
Project/Area Number |
15K21365
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
Pediatric surgery
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Research Institution | Keio University |
Principal Investigator |
YAMADA YOHEI 慶應義塾大学, 医学部(信濃町), 助教 (60383816)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 肝臓移植 / 抗体関連性拒絶反応 / 脱感作療法 / 抗ドナー抗体 / 肝細胞周囲線維化 / 肝移植 / マイクロアレイ / 抗ドナーHLA抗体 / Luminex / 肝組織線維化 |
Outline of Final Research Achievements |
This study revealed the association between the presence of anti-donor HLA antibody and the degree of fibrosis in transplanted liver grafts. The detailed analysis of the trend of donor specific antibody was performed in patients who developed acute antibody mediated rejection, and provided the clinical strategies to prevent and control humoral immunity in sensitized recipients or recipients with refractory rejection. We also reported that desensitization might prevent recurrent primary sclerosing cholangitis after liver transplantation based on the national data. In animal model, we analyzed the molecular mechanism in the binding of target endothelial cells and anti-MHC antibody, utilizing liver endothelial cells and pulmonary endothelial cells. In the microarray analysis, Proteocadherin 10 and Trpm2 are upregulated in liver endothelial cells to higher degree than pulmonary endothelial cells, which potentially indicate the protective mechanism of liver grafts.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Successful living donor liver retransplantation for graft failure within 7 days due to acute de novo donor-specific anti-human leukocyte antigen antibody-mediated rejection.2018
Author(s)
Yamada Y, Hoshino K, Mori T, Kawaida M, Abe K, Ishihama H, Shimizu T, Takahashi N, Matsubara K, Hibi T, Abe Y, Yagi H, Shimojima N, Shinoda M, Kitago M, Obara H, Fuchimoto Y, Kameyama K, Kitagawa Y, Kuroda T.
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Journal Title
Hepatol Res.
Volume: 48(3)
Issue: 3
Pages: 360-366
DOI
Related Report
Peer Reviewed
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[Journal Article] Successful management of living donor liver transplantation for biliary atresia with single ventricle physiology-from peri-transplant through total cavopulmonary connection: A case report.2018
Author(s)
Yamada Y, Hoshino K, Oyanagi T, Gatayama R, Maeda J, Katori N, Fuchimoto Y, Hibi T, Shinoda M, Matsubara K, Obara H, Aeba R, Kitagawa Y, Yamagishi H, Kuroda T.
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Journal Title
Pediatr Transplant.
Volume: 22(3)
Issue: 3
DOI
Related Report
Peer Reviewed
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[Journal Article] Rituximab Induction to Prevent the Recurrence of PSC After Liver Transplantation-The Lessons Learned From ABO-Incompatible Living Donor Liver Transplantation.2018
Author(s)
Yamada Y, Hoshino K, Fuchimoto Y, Matsubara K, Hibi T, Yagi H, Abe Y, Shinoda M, Kitago M, Obara H, Yagi T, Okajima H, Kaido T, Uemoto S, Suzuki T, Kubota K, Yoshizumi T, Maehara Y, Inomata Y, Kitagawa Y, Egawa H, Kuroda T.
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Journal Title
Transplant Direct.
Volume: 4(2)
Issue: 2
Pages: 342-342
DOI
Related Report
Peer Reviewed
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