| Project/Area Number |
15K21373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Koichi 東京大学, 大学院・医科学研究所, 特任准教授 (10360116)
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| Research Collaborator |
SAKAMOTO Kazuhiro 順天堂大学, 医学部, 教授 (60205763)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Plasmin / 炎症性疾患 / MMP-9 / 線維素溶解系 / plasmin / MMP / TNF-α / 骨髄由来細胞 / 急性肝炎 / 線維素溶解系因子 / プラスミン阻害剤 / マクロファージ / 単球 / プラスミン / 肝炎 / 血球貪食症候群 |
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| Outline of Final Research Achievements |
We prepared a severe acute hepatitis mouse model, elucidated the role of fibrinolytic system, and developed new therapy.
In the pathogenesis of acute hepatitis, the activity of coagulation and fibrinolytic factors and the activation of various MMPs (matrix metalloproteinase) were revealed. Since pathological findings of acute hepatitis were improved in these gene - deficient mice, it was revealed that MMP activity accompanying enhancement of fibrinolytic system controls acute hepatitis pathology. By administering a novel drug YO-2 that inhibits the fibrinolytic factor plasmin, inflammatory cytokines are suppressed in acute hepatitis model mice, acute hepatitis can be controlled, and future clinical applications are expected .
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