Identification of a novel gene for congenital anomalies of the kidney and urinary tract - the role of CBWD1 in the kidney development-
| Project/Area Number |
15K21385
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腎臓発生 / 先天性腎尿路異常 / 腎臓発生学 / 先天性腎尿路奇形 |
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| Outline of Final Research Achievements |
Congenital anomalies of the kidney and urinary tract (CAKUT) is the most frequent cause of pediatric chronic kidney diseases. Better understanding of the pathogenesis requires identification of novel candidate genes. So far we had focused on a gene, CBWD1, as a candidate of a new CAKUT-causing gene. The principal aim of this study was to determine whether CBWD1 plays important roles in the kidney development. Kidney develops through the reciprocal interaction between two kinds of precurssors, metanephric mesenchyme and ureteric bud. To reveal the localization of Cbwd1 in the developmental kidney, we created cross sections of the kidneys at several developmenatl stages and performed immunohistochemistry using anti-Cbwd1 antibody. Then we found that the expression of Cbwd1 was increasing in ureteric bud cells from E13.5. Next we generated knockout mice for Cbwd1 and at now we are investigating the phenotype of Cbwd1(-/-) mice.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] New-onset diabetes after renal transplantation in a patient with a novel HNF1B mutation2016
Author(s)
Kanda S, Morisada N, Kaneko N, Yabuuchi T, Nawashiro Y, Tada N, Nishiyama K, Miyai T, Sugawara N, Ishizuka K, Chikamoto H, Akioka Y, Iijima K, Hattori M.
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Journal Title
Pediatric Transplantation
Volume: 20
Issue: 3
Pages: 467-471
DOI
Related Report
Peer Reviewed
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[Presentation] 肝・胆・膵の異常2016
Author(s)
神田祥一郎、服部元史
Organizer
第59回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2016-06-17
Related Report
Invited
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[Presentation] NODAT in a pediatric patient with a novel mutation of HNF1B2016
Author(s)
Kanda S, Morisada N, Kaneko N, Yabuuchi T, Nawashiro Y, Tada N, Nishiyama K, Miyai T, Sugawara N, Ishizuka K, Akioka Y, Iijima K, Hattori M
Organizer
Transplantation Science Symposium (TSS) Asian Regional Meeting 2016
Place of Presentation
Tokyo
Year and Date
2016-04-08
Related Report
Int'l Joint Research
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