• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Upconversion Photoactivatable Polymer Gel Substrate

Research Project

Project/Area Number 15K21396
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Polymer chemistry
Research InstitutionTokyo University of Science

Principal Investigator

Kamimura Masao  東京理科大学, 基礎工学部材料工学科, 助教 (80706888)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生体材料 / アップコンバージョン / 光重合 / ナノ粒子 / バイオマテリアル / 近赤外光 / 光応答性材料 / フォトダイナミックセラピー / ポリエチレングリコール / 高分子ゲル / メカノバイオロジー / 細胞接着
Outline of Final Research Achievements

In this study, we investigated the synthesis of near-infrared to visible upconversion nanoparticles and its application for near-infrared light induced photopolymerization and activation of photosensitizer. The upconversion light induced photopolymerization was successfully performed. Furthermore, the photosensitizer immobilized upconversion nanoparticles also generated reactive oxygen species under near-infrared excitation. These obtained nanoparticles can be applied for near-infrared stimuli responsive materials.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (41 results)

All 2017 2016 2015 Other

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (27 results) (of which Int'l Joint Research: 15 results,  Invited: 8 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Ratiometric near-infrared fluorescence nanothermometry in the OTN-NIR (NIR II/III) biological window based on rare-earth doped β-NaYF4 nanoparticles2017

    • Author(s)
      Masao KAMIMURA, Taiki MATSUMOTO, Satoru SUYARI, Masakazu UMEZAWA, Kohei SOGA
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 5 Issue: 10 Pages: 1917-1925

    • DOI

      10.1039/c7tb00070g

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of OTN-NIR Bioimaging System2017

    • Author(s)
      曽我 公平、上村 真生
    • Journal Title

      Seibutsu Butsuri

      Volume: 57 Issue: 2 Pages: 081-084

    • DOI

      10.2142/biophys.57.081

    • NAID

      130005509413

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Facile Preparation of Photoactivatable Surfaces with Tuned Substrate Adhesiveness2016

    • Author(s)
      Y. Shimizu, M. Kamimura, S. Yamamoto, S. A. Abdellatef, K. Yamaguchi, and J. Nakanishi
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 11 Pages: 1183-1188

    • DOI

      10.2116/analsci.32.1183

    • NAID

      130005278006

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal <i>in vivo</i> Imaging Based on Rare-earth Doped Ceramic Nanophosphors2016

    • Author(s)
      Masao Kamimura, Rie Saito, Hiroshi Hyodo, Kosuke Tsuji, Izumi O. Umeda, Hirofumi Fujii, Kohei Soga
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 29 Issue: 4 Pages: 525-532

    • DOI

      10.2494/photopolymer.29.525

    • NAID

      130005261777

    • ISSN
      0914-9244, 1349-6336
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Control of Cell Adhesion on a Stiffness-Tunable Substrate for Analyzing the Mechanobiology of Collective Cell Migration2016

    • Author(s)
      M. Kamimura, M. Sugawara, S. Yamamoto, K. Yamaguchi, and J. Nakanishi
    • Journal Title

      Biomaterials Science

      Volume: 4 Issue: 6 Pages: 933-937

    • DOI

      10.1039/c6bm00100a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 動物体内におけるナノ粒子の未知なる動態メカニズムと検出技術改善のニーズ2016

    • Author(s)
      梅澤 雅和、新海 雄介、小野田 淳人、武田 健、上村 真生、曽我 公平
    • Journal Title

      バイオイメージング

      Volume: 25 Pages: 22-27

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NIR-II波長域を用いたマウス in vivo蛍光イメージングの可能性2016

    • Author(s)
      竹内 司、大谷 敬亨、上村 真生
    • Journal Title

      バイオイメージング

      Volume: 25 Pages: 11-15

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第2の生体の窓におけるOTN(over 1000 nm)蛍光バイオイメージング2016

    • Author(s)
      曽我 公平、上村 真生
    • Journal Title

      JSMI Report

      Volume: 9 Pages: 12-17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1000nmを超える近赤外光バイオイメージングのための蛍光ナノプローブの開発2016

    • Author(s)
      上村 真生
    • Journal Title

      バイオマテリアル-生体材料-

      Volume: 35 Pages: 24-25

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 波長1000 nmを超える近赤外蛍光イメージング2016

    • Author(s)
      上村 真生、曽我 公平
    • Journal Title

      バイオマテリアル-生体材料-

      Volume: 34 Pages: 184-189

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Surface modification on rare-earth doped ceramic nanophosphors via ligand exchange method for near-infrared biophotonics2015

    • Author(s)
      Masao Kamimura, Satoru Suyari, Taiki Matsumoto, Kohei Soga
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 28 Issue: 5 Pages: 711-713

    • DOI

      10.2494/photopolymer.28.711

    • NAID

      130005104288

    • ISSN
      0914-9244, 1349-6336
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facile preparation of a photoactivatable surface on a 96-well plate: a versatile and multiplex cell migration assay platform2015

    • Author(s)
      Masao Kamimura, Olivia Scheideler, Yoshihisa Shimizu, Shota Yamamoto, Kazuo Yamaguchi, Jun Nakanishi
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 17 Issue: 21 Pages: 14159-14167

    • DOI

      10.1039/c5cp01499a

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Over-1000 nm Near-Infrared Fluorescent Probes for Deep Tissue in vivo Imaging2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      第26回日本MRS年次大会
    • Place of Presentation
      横浜開港記念館
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Over-1000 nm Near-Infrared Luminescent Polymeric Micelles for in vivo Imaging2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka International Congress Center
    • Year and Date
      2016-12-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Over-1000 nm Near-Infrared Fluorescent Probes for Non-Invasive Deep Tissue Bioimaging2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      3rd International Conference on Biomaterials Science in Tokyo (ICBS2016)
    • Place of Presentation
      The University of Tokyo
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Fluorescence Nanoprobes for Over-1000 nm Near-infrared Bioimaging2016

    • Author(s)
      Masao Kamimura
    • Organizer
      Symposium 2016 of the Japanese Society for Biomaterials
    • Place of Presentation
      Fukuoka International Congress Center
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Over-1000 nm Near-Infrared Fluorescent Nanoprobes for in vivo Bioimaging2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      8th International Workshop on Advanced Materials Science and Nanotechnology
    • Place of Presentation
      Ha Long City, Vietnam
    • Year and Date
      2016-11-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Fluorescence Nanoprobes for Over-1000 nm Near-infrared Bioimaging2016

    • Author(s)
      Masao Kamimura
    • Organizer
      20th Anniversary International Symposium of the Korean Society for Biomaterials 2016
    • Place of Presentation
      KIST, Seoul, Korea
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 近赤外蛍光高分子ミセルによる波長1000nmを超えるin vivoイメージング2016

    • Author(s)
      上村 真生、高廣 祥子、吉田 萌、曽我 公平
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学横浜キャンパス
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Near-Infrared Dye-Loaded Polymer Micelles for Over-1000 nm Fluorescence in vivo Imaging2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      Biointerfaces International 2016
    • Place of Presentation
      University of Zurich, City Campus, Zurich, Switzerland
    • Year and Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Over-1000 nm NIR Luminescence Thermometry at the Nanoscale: An Analytical Technique for Mechanobiology2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      2nd International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      National Institute for Materials Science, Tsukuba, Japan
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biocompatible Polymer-conjugated Inorganic Nanophosphors for Near-infrared in vivo Imaging in the Second Biological Window2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      HTCMC9 and GFMAT2016
    • Place of Presentation
      Toronto Marriott Downtown Eaton Center Hotel, Toronto, Canada
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Over-1000 nm Near-infrared Fluorescence and SPECT Dual-modal in vivo Imaging Based on Rare-earth Doped Ceramic Nanophosphors2016

    • Author(s)
      Masao Kamimura, Rie Saito, Hiroshi Hyodo, Kosuke Tsuji, Izumi O. Umeda, Hirofumi Fujii, Kohei Soga
    • Organizer
      The 33rd International Conference of Photopolymer Science and Technology
    • Place of Presentation
      Makuhari Messe, Chiba, Japan
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「第2の生体の窓」における近赤外蛍光in vivoイメージング2016

    • Author(s)
      上村 真生、曽我 公平
    • Organizer
      バイオイメージ・インフォマティクスワークショップ 2016
    • Place of Presentation
      大阪大学吹田キャンパス
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 1000 nmを超える近赤外光バイオイメージングに向けた蛍光プローブの開発2016

    • Author(s)
      上村 真生、曽我 公平
    • Organizer
      第76回分析化学討論会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 1000 nmを超える近赤外光バイオイメージングのための蛍光ポリマーミセルの設計2016

    • Author(s)
      上村 真生、高廣 祥子、曽我 公平
    • Organizer
      第65回高分子年次会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Polymer/inorganic phosphor nanocomplex for near-infrared biophotonics in the second biological window2016

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 近赤外蛍光ナノ粒子を利用するナノ温度イメージング2016

    • Author(s)
      上村 真生、曽我 公平
    • Organizer
      日本化学会 第96春季年会
    • Place of Presentation
      同志社大学京田辺キャンパス
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Nanothermometry in the Second Biological Window Based on Temperature Dependent Near-infrared Fluorescence of Rare-earth Doped Ceramic Nanophosphors2015

    • Author(s)
      Masao Kamimura, Taiki Matsumoto, Satoru Suyari, Kohei Soga
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 第2の生体の窓を利用する近赤外蛍光ナノ温度イメージング2015

    • Author(s)
      上村 真生、松本 泰来、須鎗 聡、曽我 公平
    • Organizer
      第37回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2015-11-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 光を利用するバイオマテリアルの研究 -基礎研究から診断・治療への展開-2015

    • Author(s)
      上村 真生
    • Organizer
      第26回バイオマテリアル若手研究会
    • Place of Presentation
      八王子セミナーハウス
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] PEG化セラミックスナノ粒子を用いた近赤外蛍光ナノ温度計2015

    • Author(s)
      上村 真生、松本 泰来、須鎗 聡、曽我 公平
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 希土類含有セラミックスナノ粒子の近赤外発光を用いたナノ温度イメージング2015

    • Author(s)
      上村 真生、松本 泰来、須鎗 聡、曽我 公平
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大学伊都キャンパス
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Surface Modified Rare-earth Doped Ceramic Nanophosphors for Fluorescence Bioimaging and Nanothermometry in the Second Biological Window2015

    • Author(s)
      Masao Kamimura, Kohei Soga
    • Organizer
      2015 International Symposium on Chemical and Polyscale Technologies for Biomedical Application and Environmental Sustainability (ISCPT)
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Introducing a photoactivatable feature on stiffness-tunable gels for the study of mechanobiology in collective cell migration2015

    • Author(s)
      Masao Kamimura, Michiko Sugawara, Kazuo Yamaguchi, Jun Nakanishi
    • Organizer
      International Symposium on Nanoarchitectonics for Mechanobiology
    • Place of Presentation
      National Institute for Materials Science, Tsukuba, Japan
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel nanothermal sensing based on over-1000 nm near-infrared emission of rare-earth doped ceramic nanophosphors2015

    • Author(s)
      Masao Kamimura, Taiki Matsumoto, Kohei Soga
    • Organizer
      ICMAT2015&IUMRS-ICA2015
    • Place of Presentation
      Suntec Singapore, Singapore
    • Year and Date
      2015-06-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surface modification on rare-earth doped ceramic nanophosphors via ligand exchange method for near-infrared biophotonics2015

    • Author(s)
      Masao Kamimura, Satoru Suyari, Taiki Matsumoto, Kohei Soga
    • Organizer
      The 32nd International Conference of Photopolymer Science and Technology
    • Place of Presentation
      Makuhari Messe, Chiba, Japan
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] リガンド交換法によるPEG化希土類含有セラミックスナノ粒子の作製と近赤外バイオフォトニクスへの応用2015

    • Author(s)
      上村 真生、松本 泰来、須鎗 聡、曽我 公平
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Temperature dependent near-infrared emission of rare-earth doped ceramic nanophosphors in the second biological window for sensitive nanothermal imaging2015

    • Author(s)
      Masao Kamimura, Taiki Matsumoto, Kohei Soga
    • Organizer
      The 5th Asian Biomaterials Congress
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-05-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 月刊バイオインダストリー2016

    • Author(s)
      上村 真生、曽我 公平
    • Total Pages
      7
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/fac_grad/p/index.php?696d

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi